急性肺损伤血清氨基末端脑钠肽前体、白细胞介素-6及肿瘤坏死因子-α变化的临床意义

目的探讨氨基末端脑钠肽前体(NT-pro BNP)、白细胞介素-6(IL-6)及肿瘤坏死因子(TNF-α)和急性肺损伤之间的相互关系,为急性肺损伤诊断提供佐证并提示预后情况。方法随机顺序选取60例我院ICU收治的急性肺损伤患者为观察组,招募24例正常人为对照组。采用电化学发光免疫检测血浆NT-pro BNP、酶联免疫吸附试验检测IL-6及TNF-α水平变化,同时进行肺损伤评分,分析其相关性。结果 (1)急性肺损伤患者血浆NT-pro BNP、IL-6及TNF-α水平高于对照组(P0.05);(2)血浆NT-pro BNP、IL-6及TNF-α水平与肺损伤评分呈正相关(r=0.7031;P0.05);(3)急性肺损伤患者治疗后血浆NT-pro BNP、IL-6及TNF-α较治疗前降低(P0.05)。结论血清NT-pro BNP、IL-6及TNF-α水平在急性肺损伤患者中上调,肺损伤评分联合血清NT-pro BNP、IL-6及TNF-α测定可作为急性肺损伤严重程度评价和预后判断的重要标志。

Changes of N-terminal pro-B-type natriuretic peptide,interleukin-6, and tumor necrosis factor-αplasma levels in patients with acute lung injury

Objective To explore the relationship between N-terminal pro-B-type natriuretic peptide ( NT-proBNP ) and acute lung injury as well as interleukin-6 ( IL-6 ) and tumor necrosis factor-α( TNF-α) . Methods All 60 patients with acute lung injury were allocated to observation group and 24 normal cases were recruited to control group. The serum levels of NT-proBNP, IL-6 and TNF-α were detected by the electrochemical luminescence immunoassay, ELISA respectively. Results (1) The serum NT-proBNP, IL-6 and TNF-α levels in patients with acute lung injury were higher than those in control group (P<0.05); (2) The serum NT-proBNP, IL-6 and TNF-α levels were positively correlated with lung injury score (r=0.7031;P<0.05);(3) After treatment, the serum NT-proBNP, IL-6 and TNF-αlevels were decreased in patients with acute lung injury (P<0.05). Conclusion The serum levels of NT-proBNP, IL-6 and TNF-αare increased in patients with acute lung injury. Lung injury score combines with serum NT-proBNP, IL-6 and TNF-αlevels are important biomarkers for acute lung injury and its prognosis.