慢性乙丙型肝炎重叠感染后血清病毒标志物的变化

目的为了探讨病毒之间的干扰现象，作者对慢性乙丙型病毒性肝炎重叠感染患者的血清肝炎病毒标志物的变化进行研究。方法１９９２年１月＿１９９４年１０月连续在我院住院确诊的慢性乙丙型病毒性肝炎重叠感染患者６０例，同期连续收住院的单纯慢性乙型肝炎患者１１０例作为对照组，比较两组患者入院时的血清乙型肝炎病毒标志物，并对观察组中２０例患者进行了随访，随访期０．５＿３年。结果入院时观察组ＨＢｅＡｇ和抗＿ＨＢｃＩｇＭ阳性率较对照组显著减少（１９／６０对５２／１０６，８／６０对２９／１１０，Ｐ＜０．０５），ＨＢｓＡｇ阴性率和抗＿ＨＢｅ阳性率显著增高（１０／／６０对５／１１０，Ｐ＜０．０１；３８／６０对４８／１０６，Ｐ＜０．０５）。观察组２０例随访发现，ＨＢＶ＿ＤＮＡ阳性及ＨＢＶ＿ＤＮＡ，ＨＣＶ＿ＲＮＡ二项同时阳性例数都比入院时明显减少（４／２０对１０／２０，Ｐ＜０．０５；１／２０对７／２０，Ｐ＜０．０５）。结论慢性乙丙型病毒性肝炎重叠感染时存在病毒干扰现象

The changes of serum virus markers after superinfeection with HBV and HCV in chronic hepatitis

AIMS To demonstrate the interference between viruses, the changes of serum hepatitis virus markers in patients of chronic hepatitis of superinfection with hepatitis B virus(HBV) and C virus(HCV). METHODS From Jan. 1992 to Oct. 1994, were studied patients with chronic hepatitis of confirmed superinfection with HBV and HCV admitted in our hospital were taken as an observed group. Another 110 consecutive hospitalized patients with chronic hepatitis B alone during the same period were selected as controls and those patients. Serum hepatitis B virus markers(HBVM) of patients between two groups at the time of admission were compared and follow_up survey was performed in 20 patients of observed group, and the follow_up time was 0.5 to 3 years. RESULTS The positive rate for HBeAg and anti_HBcIgM was lower(19/60 vs 52/106,8/60 vs 29/110, <0.05), negative rate for HBsAg and positive rate for anti_HBe was higher (10/60 vs 5/110, P<0.01; 38/60 vs 48/106, P<0.05) in observed group than those in controls at the time of admission. The number of positive objects for HBV_DNA, and both HBV_DNA and HCV_RNA were significantly decreased(4/20 vs 10/20, P<0.05; 1/20 vs 7/20, P<0.05) than those at the time of their admission in 20 follow_up patients of observed group. CONCLUSIONS There is phenomenon of interference of viruses between HBV and HCV superinfection in patients with chronic hepatitis.