CD15s和CD138在肝细胞癌中的表达及其意义

目的探讨CD15s和CD138表达与肝细胞癌(HCC)转移和预后的关系。方法应用免疫组织化学方法,检测1990年2月至2006年5月110例肝细胞癌组织中CD15s和CD138蛋白表达状况,并结合随访资料进行分析。结果 CD15s和CD138在HCC中阳性表达率分别为39.1%和46.4%。CD15s阳性表达的HCC转移率高(P0.05),分化程度及患者5年存活率低(P0.05);CD138阳性表达的HCC转移率低(P0.05),分化程度及患者5年存活率高(P0.05)。CD15s表达与CD138表达呈负相关(P0.05)。结论 CD15s和CD138表达与HCC转移和患者生存期密切相关,检测CD15s和CD138蛋白的表达可作为判断HCC预后有价值的参考指标。

Expression and implication of CD15s and CD138 in hepatocellular carcinoma

Objective To investigate the relationship of D15s and CD138 in invasion and metastasis of hepatocellular carcinoma （HCC）.Methods Immunohistochemical method was used to detect CD15s and CD138 expression in 110 cases of HCC from February 1990 to May 2006.Results Positive expression rate of CD15s and CD138 in HCC were 39.1% and 46.4%,respectively.HCC with positive expression of CD15s had higher metastatic rate（P0.05）,poorer 5-years survival rate（P0.05）;HCC with positive CD138 expression had lower metastatic rate（P0.05） and higher 5-years survival rate（P0.05）.The expression of CD15s was negatively correlated to CD138 expression in HCC（P0.05）.Conclusions The expression of CD15s and CD138 is closely related to the potential of metastasis and survival rate in HCC.CD15s and CD138 may be clinically used as prognostic indicators in HCC.