非洛地平缓释片与苯那普利治疗原发性高血压病的疗效比较

目的：比较非洛地平缓释片与苯那普利的降压疗效。方法：130例原发性高血压患者随机分为非洛地平缓释片组（F组）与苯那普利组（B组），123例完成治疗。结果：降压幅度F组均高于B组，但差异尤显著性（P＞0．05）。2周后F组与B组的降压总有效率为66．7％、48．7％；4周后降压总有效率为87．3％、68．3％。两组比较均有显著性差异（P＜0．05）。两药不良反应均较少。结论：两药均为有效、耐受性好的降压药，而在降压效果方面非洛地平缓释片5～10mg／d优于苯那普利10～20mg／d。

11||THE EFFICACY OF FELODIPINE-ER VERSUS BEZANAPRIL IN PATIENTS WITH ESSENTIAL HYPERTENSION

Aim: to compare the efficacy of Felodipine - ER with that of Bezanapril. Method: ahundred and thirty patients with essential hypertension were randomly divided into Felodipine - ER group(F group) and Bezanpril group (B group). 123 patients completed the study. Result: alI the reductionof BP in F group was more than that in B group. But the difference between two groups wasn' t statisti-cally significant (P >0. 05). After 2 weeks, the total effective rate in F group was 66. 7%, whereasit in B group was 48. 7% (P <0.05). After 4 weeks, the total effective rate was 87. 3% and 68.3% respectively (P <0.05). The inciclance of adverse effects was lower and adveres effects were mild.Condusion: both Felodipine - ER and Bezanapril are effective and well toleraled in freating the essential hy-pertension. However, Felodipine - ER 5 ～ 10mg/d is more effective than Bezanapril 10～ 20mg/d in con-troling high blood pressure.