HLA antigens are candidate markers for prediction of lymph node metastasis in gastric cancer |
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| Authors: | Kyogi Ogoshi Tomoo Tajima Toshio Mitomi Kimiyoshi Tsuji |
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| Institution: | (1) Department of Surgery, Tokai University, School of Medicine, Kanagawa, Japan;(2) Transplantation Immunology, Tokai University, School of Medicine, Kanagawa, Japan;(3) Department of Surgery, School of Medicine, Tokai University, 259-11 Bohseidai Isehara, Kanagawa, Japan |
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| Abstract: | We investigated the association between human leucocyte antigen (HLA) antigens and lymph node metastasis in 724 gastric cancer patients. Among patients who had poorly differentiated adenocarcinoma with or without HLA-DR4 antigen, lymph node metastasis was detected in 80.8 and 54.9%, respectively (relative risk (RR)=3.5, P = 0.0005, corrected P = 0.0285). It was more common in patients with a family history of cancer death (RR = 7.7). Among signet ring cell carcinoma patients with or without HLA-1152 antigen, lymph node metastasis was detected in 57.7 and 19.7%, respectively (RR =5.6, P=0.0001, corrected P=0.0086). It was more common in patients who were smokers (RR = 8.3). Our findings suggest that HLA-DR4 and HLA-1152 antigens are associated with lymph node metastasis in gastric cancer. |
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| Keywords: | cancer family history gastric cancer HLA-1152 and HLA-DR4 antigens lymph node metastasis smoking habit |
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