带状疱疹急性期应用卡维地洛预防疱疹后神经痛的研究

目的 探讨带状疱疹急性期应用卡维地洛预防疱疹后神经痛（PHN）的可行性及效果。方法 将60例急性期带状疱疹患者随机分为干预组和对照组，每组30例。两组均给予常规治疗14d，包括抗病毒、营彝神经、消炎止痛和神经安定药物；干预组在此基础上给予卡维地洛10mg，1次／d，共14d。分别于治疗前及治疗后2、4、8、12周进行疼痛评估。观测指标包括神经病理性疼痛评分（NPS）、视觉模拟评分（VAS）、痛觉过敏、触诱发痛、痛觉总和及感觉后遣现象。结果 干预组VAS、NPS低于对照组（P分别〈0．05、0．01），NPS中不适感、癀痒和烧灼感的主诉明显少于对照组（P分别〈0．01、0．01、0．05）。对照组PHN的发生率为26．6％（8／30），干预组为3．33％（1／30），P〈0．05。结论 带状疱疹急性期应用卡维地洛可降低PHN的发生率，并能缓解急性期症状。

Study on the prevention of PHN by carvedilol administrated in acute herpes-zoster

Objective: To estimate the feasibility of preventing PHN by using carvedilol in acute phase of zoster.Methods: 60 cases of zoster in acute phase were didvided ramdomly into control group and carvedilol group with 30 cases in each group.Both groups were treated with routine methods and carvedilol group was given carvedilol additionally.NPS,VAS,summation,after sensation,hyperalgia and allodynia were observed.Results: VAS,NPS and occurence rate of PHN in carvedilol group were lower than that in control group(P<(0.05),<0.01,<0.05).Conclusions: Use of carvedilol in acute phase of zoster may decrease the occurrence rate of PHN and remit symptom.