Pathologic features of early inflammatory bowel disease |
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Authors: | Finkelstein Sydney D Sasatomi Eizaburo Regueiro Miguel |
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Affiliation: | Department of Pathology, Division of Gastroenterology, Nutrition and Hepatology, University of Pittsburgh Medical Center, 200 Lothrop Street, PUH A610.2, Pittsburgh, PA 15213, USA. |
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Abstract: | Often the pathologic changes of IBD are subtle and may not be present in a proportion of biopsy specimens. In cases of early disease, the changes may be missed, and additional specimens should be taken after a period of time. Modifying factors, such as prebiopsy treatment and coexisting disease, should be considered. A forum to review cases and allow for communication between gastroenterologists and pathologists is especially useful for clinicopathologic correlation and assignment of a working diagnosis to each case. Careful attention to the pathologic features of early UC and CD would be most useful when evaluating new therapies for IBD. |
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