| 诱导胚胎干细胞向软骨细胞分化研究进展 |
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| 引用本文： | 石伦刚,张文杰. 诱导胚胎干细胞向软骨细胞分化研究进展[J]. 国际生物医学工程杂志, 2008, 31(3) |
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| 作者姓名： | 石伦刚 张文杰 |
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| 作者单位： | 200011,上海交通大学医学院附属第九人民医院整形外科组织工程国家工程中心;200011,上海交通大学医学院附属第九人民医院整形外科组织工程国家工程中心 |
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| 基金项目： | 国家自然科学基金，上海市浦江人才计划 |
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| 摘 要： | 胚胎干细胞因其具有体外无限增殖能力和体内外分化发育的全能性,有望为细胞治疗或组织工程化组织构建提供可靠的种子细胞来源.如何诱导胚胎干细胞向目的细胞分化是目前面临的一大难题.首先回顾软骨细胞的体内发生、发育过程,继而对目前已知的能在体外培养环境中影响胚胎干细胞向软骨细胞分化的各类因素进行分析综述,并探讨进一步的研究方向.
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| 关 键 词： | 胚胎干细胞 软骨细胞 软骨形成 分化 |
Research progress in chondrogenic differentiation of embryonic stem cells |
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| SHI Lun-gang,ZHANG Wen-jie. Research progress in chondrogenic differentiation of embryonic stem cells[J]. International Journal of Biomedical Engineering, 2008, 31(3) |
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| Authors: | SHI Lun-gang ZHANG Wen-jie |
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| Abstract: | Since the first successful establishment of human embryonic stem cell line in 1998,embryonic stem cell research has attracted much attention in recent years.Theoretically,embryonic stem cells are pluripotent 0f in vitro proliferation and in vivo differentiation.which could serve as a promising seed cell source for cell thera PY or tissue engineering.Differentiation of the embryonic stem cells into a certain type of cell still remains a big challenge.Studies regarding chondrogenic ifferentiation have been reported.This article summarizes the chon drogenic process in developing embryo and the currently known factors involved in the in vitro chondrogenic differentiation of embryonic stem cell.Foreground of the study in this field is discussed. |
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| Keywords: | Embryonic stem cell Chondrocyte Chondrogenesis Differentiation |
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