| 单态氧猝灭剂叠氮钠治疗角膜碱烧伤实验研究 |
| |
| 引用本文： | 邱良秀,张泺,沈远平.单态氧猝灭剂叠氮钠治疗角膜碱烧伤实验研究[J].华中科技大学学报(医学版),2001,30(5):495-496. |
| |
| 作者姓名： | 邱良秀 张泺 沈远平 |
| |
| 作者单位： | 华中科技大学同济医学院附属同济医院眼科,武汉,430030 |
| |
| 摘 要： | 为研究叠氮钠对角膜碱烧伤的治疗作用,在家兔的角膜碱烧伤模型中,用1 g/L NaN3及10 g/L NaN3+100g/L枸橼酸钠滴眼剂治疗.同时用硫代巴比妥酸(TBA)反应法检测过氧化脂质(LPO),用组织培养人角膜上皮细胞检测NaN3毒性,发现角膜烧伤后LPO逐渐减少.治疗组病情较轻,且NaN3毒性低,认为角膜碱烧伤后,用NaN3治疗有一定效果.
|
| 关 键 词： | 单态氧 叠氮钠 角膜碱烧伤 |
| 修稿时间： | 2000年11月13 |
The Singlet Oxygen Scavenger Sodium Azide in the Treatment of Alkaline Burn of Cornea: An Experimental Study |
| |
| Qiu Liangxiu,Zhang Luo,Shen Yuanping.The Singlet Oxygen Scavenger Sodium Azide in the Treatment of Alkaline Burn of Cornea: An Experimental Study[J].Journal of Huazhong University of Science and Technology(Health Sciences),2001,30(5):495-496. |
| |
| Authors: | Qiu Liangxiu Zhang Luo Shen Yuanping |
| |
| Institution: | Qiu Liangxiu,Zhang Luo,Shen Yuanping Department of Ophthalmology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030 |
| |
| Abstract: | The therapeutic effects of sodium acide (NaN 3), an agent of singlet oxygen scavenger, in the treatment of alkaline burn of cornea was investigated in a dose of 1 g/L NaN 3 or 1 g/L NaN 3 100 g/L Sod. Citrate. LPO was determined by TBA fluorophotmeter. The toxicity of NaN 3 was detected by tissue culture assay. It was found that LPO was decreased gradually after alkaline burn. The therapeutic effect of NaN 3 were better than in the control group. The toxicity of NaN 3 was slight. It was suggested the use of NaN 3 in alkaline burn of cornea was considerable. |
| |
| Keywords: | singlet oxygen sodium acide alkaline burn of cornea |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
