Population study of 3 STR loci in the Basque Country (northern Spain) |
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Authors: | S. Alonso A. Castro I. Fernandez M. Gömez de Cedrön A. Garcia-Orad E. Meyer M. Martínez de Pancorbo |
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Affiliation: | (1) Dpto. de Biología Celular y CC. Morfológicas, Facultad de Medicina, Universidad del País Vasco, E-48940 Leioa, Bizkaia, Spain;(2) Institut für Rechtsmedizin, Universität Münster, D-48149 Münster, Germany;(3) Instituto Vasco de Criminología, Avda. Ategorrieta 22, E-20013 San Sebastian, Spain |
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Abstract: | The tetrameric STRs, HUMTH01, HUMVWA31A and HUMFES/FPS, were studied in a population from the Basque Country (northern Spain) for their frequency distribution and applicability to identity and paternity testing. All systems conformed to Hardy-Weinberg equilibrium; pairwise comparisons demonstrated the allelic independence between loci, and furthermore, all systems seemed to be in agreement with expectations from the Stepwise Mutation Model (SMM) of the mutation-drift theory, which indicates the homogeneity of the population and suggests a replication slippage mechanism as a possible model for generating alleles. A comparison with other population groups appeared to indicate that frequencies are well conserved in Caucasians, but differ from other racial groups. The calculated parameters a priori probability of exclusion (PEX) and index of discrimination (ID), show the informativeness of these loci for the determination of identity and relatedness of individuals. |
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Keywords: | STR HUMTH01 HUMVWA31/A HUMFES/FPS Population genetics |
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