Absence of a directly causative role for human herpesvirus 7 in human lymphoma and a review of human herpesvirus 6 in human malignancy |
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| Authors: | Z N Berneman G Torelli M Luppi R F Jarrett |
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| Institution: | (1) Division of Hematology, Antwerp University Hospital, University of Antwerp, Wilrijkstraat 10, B-2650 Edegem, Belgium e-mail: zwi.berneman@uza.uia.ac.be, Tel.: 0032-3-821-3780, Fax: 0032–3-825-3318), BE;(2) Center for Experimental Hematology, Department of Medical Sciences, University of Modena, Modena, Italy, IT;(3) Leukaemia Research Fund Virus Centre at the University of Glasgow, Department of Veterinary Pathology, Veterinary School, Glasgow, Scotland, GB |
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| Abstract: | In search of a (new) viral etiological agent, we screened 64 lymph node samples from Hodgkin's disease (HD) and 43 samples
(32 lymph node and 11 skin biopsies) from non-Hodgkin's lymphoma (NHL) for human herpesvirus 7 (HHV-7). Twenty-nine control
samples were tested as well, including 17 with benign lymphadenopathy. None of the samples tested positive by Southern blot
hybridization using HHV-7-specific probes. We conclude that there is no major HHV-7 load in human lymphoma and that HHV-7
is not likely to be directly involved in its etiology. This is in contrast to a small minority of human lymphoproliferative
diseases in which HHV-6 can be found at high copy number, but in which an etiological role is still uncertain.
Received: September 8, 1998 / Accepted: November 2, 1998 |
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| Keywords: | Hodgkin's disease Non-Hodgkin's lymphoma Human herpesvirus 7 Human herpesvirus 6 Viral etiology |
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