Review: hepatitis B immune globulin for prevention of hepatitis B infection |
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| Authors: | Zuckerman J N |
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| Institution: | Academic Centre for Travel Medicine and Vaccines, WHO Collaborating Centre for Reference, Research and Training in Travel Medicine, Royal Free & University College Medical School, University College London, UK. j.zuckerman@medsch.ucl.ac.uk |
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| Abstract: | Specific hepatitis B immune globulin (HBIG) contains a high titer of antibody to hepatitis B surface antigens and provides immediate passive protection against infection with hepatitis B virus, after acute exposure to infection. It is now generally combined with active immunization with hepatitis B vaccine. The principal indications for administration of HBIG are: a single acute percutaneous exposure to hepatitis B virus (HBV); mucocutaneous exposure; unprotected sexual exposure; mother-to-infant transmission; prevention of re-infection after liver transplantation; non-responders to hepatitis B vaccine and immunosuppressed patients. |
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| Keywords: | HBIG passive prophylaxis indications for HBIG |
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