| 乳腺癌新辅助化疗对凋亡相关基因p53、bc1-2的影响(英文) |
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| 引用本文： | 代志军,王西京,马卉,刘小旭,薛峰杰,薛兴欢,康华峰. 乳腺癌新辅助化疗对凋亡相关基因p53、bc1-2的影响(英文)[J]. 现代肿瘤医学, 2006, 0(1) |
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| 作者姓名： | 代志军 王西京 马卉 刘小旭 薛峰杰 薛兴欢 康华峰 |
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| 作者单位： | 西安交通大学第二医院肿瘤科 陕西西安710004 |
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| 摘 要： | 目的探讨乳腺癌新辅助化疗对凋亡相关基因p53、bcl-2表达的影响及其意义。方法用免疫组织化学ABC法检测97例新辅助化疗(研究组)和同期76例未行新辅助化疗(对照组)的乳腺癌组织p53、bcl-2蛋白的表达,并结合5年无病生存率(DFS)进行分析。结果研究组p53阳性率为28.9%(28/97),对照组为38.2%(29/76);研究组bcl-2阳性率为40.2%(39/97),对照组为56.7%(43/76);研究组5年DFS为74.2%(72/97),对照组为60.5%(46/76),两者比较均有显著差异。结论新辅助化疗通过凋亡相关基因p53、bcl-2的表达影响预后。
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| 关 键 词： | 乳腺肿瘤 新辅助化疗 p53 bcl-2 |
Siginificance of neoadjuvant chemotherapy on expression of p53/bcl-2 in breast cancer |
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| DAI Zhi-jun,WANG Xi-jing,MA Hui,LIU Xiao-xu,XUE Feng-jie,XUE Xing-huan,KANG Hua-feng. Siginificance of neoadjuvant chemotherapy on expression of p53/bcl-2 in breast cancer[J]. Journal of Modern Oncology, 2006, 0(1) |
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| Authors: | DAI Zhi-jun WANG Xi-jing MA Hui LIU Xiao-xu XUE Feng-jie XUE Xing-huan KANG Hua-feng |
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| Affiliation: | DAI Zhi-jun,WANG Xi-jing,MA Hui,LIU Xiao-xu,XUE Feng-jie,XUE Xing-huan,KANG Hua-feng Department of Oncology,Second Hospital,Xi'an Jiaotong University,Xi'an 710004,China. |
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| Abstract: | Objective To study the significance of neoadjuvant chemotherapy on p53/bcl-2 expression in breast cancer.Methods The study group which was treated with neoadjuvant chemotherapy(n=97) and the control group which did not accept neoadjuvant chemotherapy(n=79) were analyzed for expression of p53/bcl-2,and the DSF was also analyzed.Results p53 protein was expressed in 28 of 97 cases(28.9%) in study group,while 29 of 76 cases(38.2%) in control group;bcl-2 protein was expressed in 39 of 97 cases(40.2%) in study group,while 43 of 76 cases(56.7%) in control group;5 year-DFS in study group was 74.2%(72/79),while 60.5%(46/76) in control group.All the result was statistically significant.Conclusion It is possible that neoadjuvant chemotherapy can improve prognosis through adjusting expression of p53/bcl-2. |
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| Keywords: | breast cancer neoadjuvant chemotherapy p53 bcl-2 |
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