| 血管内皮生长因子C大鼠碱烧伤角膜中的表达 |
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| 引用本文： | 凌士奇,胡燕华,赵巍,徐惠民.血管内皮生长因子C大鼠碱烧伤角膜中的表达[J].眼外伤职业眼病杂志,2003,25(12):798-799. |
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| 作者姓名： | 凌士奇 胡燕华 赵巍 徐惠民 |
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| 作者单位： | 华中科技大学同济医学院附属协和医院眼科,湖北,武汉,430022 |
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| 摘 要： |
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| 关 键 词： | 血管内皮生长因子C 角膜 碱烧伤 |
| 文章编号： | 1004-6461(2003)12-0798-02 |
| 修稿时间： | 2003年3月21日 |
The expression of VEGF-C in cornea after alkali burn in rats. |
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| LING Shi_qi,HU Yan_hua,ZHAO Wei,et al..The expression of VEGF-C in cornea after alkali burn in rats.[J].Journal of Injuries and Occupational Diseases of the Eye with Ophthalmic Surgeries,2003,25(12):798-799. |
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| Authors: | LING Shi_qi HU Yan_hua ZHAO Wei |
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| Affiliation: | LING Shi_qi,HU Yan_hua,ZHAO Wei,et al.Department of Ophthalmology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology.Wuhan 430022,China |
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| Abstract: | Objective To study the expression of VEGF_C in corneas and the molecular mechanism of lymphangiogensis after corneal alkali burn in rats.Methods The corneal alkali burn animal models were made.Then examined the expression of VEGF_C protein by immunohistochemistry on the 1 st,3rd,5th,7th,9th day after the injury respectively and quantited the level of VEGF_C mRNA with the RT-PCR technology on the 5th day after injury. In addition,the presence of lymphatic vessels in the rat injuried corneas was examined with electron microscope.Resuts The VEGF-C expression in the corneas of rats was dramatically up_regulated after the injury,and on the 14th day after the injury, lymphatic vessels were present in the corneas.Conclusion VEGF_C may be one of an important relevant endogenous factors in corneal lymphangiogensis after alkali burn. |
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| Keywords: | vasular endothelial growth factor C cornea alkail burn |
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