红细胞分布宽度、胱抑素C与冠状动脉病变程度的相关性分析

目的:探讨红细胞分布宽度、胱抑素C与冠状动脉粥样硬化病变程度的关系。方法:选取住我院拟诊冠心病患者,依据冠状动脉造影检查结果将其分为冠状动脉正常组、单支病变组和多支病变组,对三组资料进行分析比较,并应用Logistic回归分析冠状动脉病变的危险因素。结果:共纳入患者267例,平均年龄(65.5±8.8)岁,其中正常组66例,单支病变组87例,多支病变组114例,三组资料在TC、同型半胱氨酸、红细胞分布宽度及胱抑素C,差异有统计学意义,Logistic回归分析显示:冠状动脉病变程度与TC(OR=4.020,95%CI:2.248,7.189,P=0.000)、血糖(OR=1.677,95%CI:1.100,2.556,P=0.016)、同型半胱氨酸(OR=1.155,95%CI:1.042,1.281,P=0.006)、红细胞分布宽度(OR=1.938,95%CI:1.042,3.604,P=0.037)、胱抑素C(OR=9.099,95%CI:4.869,13.330,P=0.000)呈正相关,与舒张压(OR=0.944,95%CI:0.893,0.999,P=0.044)呈负相关。结论:在冠状动脉粥样硬化病变的传统危险因素TC、血糖、同型半胱氨酸之外,红细胞分布宽度、胱抑素C也可能是其独立危险因素,并且有可能成为冠心病新的防治途径,在临床中应加以重视。

Correlation of red cell distribution width,cystatin C and the degree of coronary atherosclerosis

Objective： To study the relationship between red cell distribution width, cystatin C in the peripheral blood and the degree of coronary atherosclerosis. Methods： Patients with suspected myocardial is ehemia who underwent coronary angiography in our hospital were divided into the single angiopathy group,multi ple angiopathy group and the normal control group according to the result of coronary arteriongraphy. Logistic regression was used to identify the risk factor of the degree of coronary atheroselerosis. Results ：267 patients with an average age of （65.5 ±8.8 ） years involving 66 patients with normal coronary artery, 87 patients with single vessel disease and 114 patients with multivessel disease were included. The factors of total cholesterol, homo eysteine, red cell distribution width,cystatin C were significantly different between the three groups. Multivari ate logistic regression models found that the factors of total cholesterol （OR = 4. 020,95% CI： 2. 248,7. 189, P = O. 000 ）, blood glucose （ OR = 1. 677,95 % C1：1.100,2. 556, P = 0. 016 ） , homocysteine （ OR = 1.155,95 % CI： I. 042, I. 281 ,P = 0. 006 ）, red cell distribution width （ OR = I. 938,95% CI： 1. 042,3. 604, P = 0. 037 ）, cystatin C （OR = 9. 099, 95% CI： 4. 869,13. 330, P = 0. 000） were positively associated with lesion degree of coronary artery. And the diastolic blood pressure （ OR = 0. 944,95% CI：0. 893,0. 999 ,P = 0. 044 ） were nega tively correlated with it. Conclusion： Except for traditional risk （cholesterol, glucose, homoeysteine）, the red cell distribution width and eystatin C may also be independent risk factors for coronary heart disease. It may be come a new prevention a~proaeh and more attention should be paid in clinical practice.