复方利巴韦林滴鼻液的制备及质量控制

目的：对复方利巴韦林滴鼻液的制备及质控方法进行研究。方法：参照同类制剂，选择利巴韦林及盐酸麻黄碱作为主药，辅以甘油、氯化钠、苯扎溴铵配成滴鼻液，分别采用分光光度法测定利巴韦林含量，中和法测定盐酸麻黄碱含量。结果：利巴韦林的平均回收率为99．9％(RSD=0．2％)，盐酸麻黄碱的平均回收率为100．2％(RSD=0．3％)。结论：本制剂制备工艺简单，稳定性好，含量测定方法简便易行，结果准确，适用于医院制剂室配制和进行质量控制。

Preparation and Quality Control of Compound Ribavirin Nasal Drops

Objective: To prepare the compound ribavirin nasal drops and study the quality control method.Methods: The ultraviolet spectrophotometry and acid basetitration were used to determinate ribavirin and ephedrine hydrochloride.Result: The average recoveries and RSD were 99.9% , 0.2% for ribavirin and 100.2% , 0.3% for ephedrine hydrochloride.Conclusion: The method was simple and accurate and could be used for the quality control of compound ribavirin nasal drops.