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外周血T淋巴细胞亚群检测在胃癌病情监测及预后评价中的意义
引用本文:王展梅,曹芳丽,曲琳莉,王欢. 外周血T淋巴细胞亚群检测在胃癌病情监测及预后评价中的意义[J]. 癌症进展, 2016, 14(4). DOI: 10.11877/j.issn.1672-1535.2016.14.04.22
作者姓名:王展梅  曹芳丽  曲琳莉  王欢
作者单位:山东大学齐鲁医院 青岛 化疗科,山东青岛,266000;山东大学齐鲁医院 青岛 化疗科,山东青岛,266000;山东大学齐鲁医院 青岛 化疗科,山东青岛,266000;山东大学齐鲁医院 青岛 化疗科,山东青岛,266000
摘    要:目的:探讨外周血T淋巴细胞亚群检测在胃癌病情监测及预后评价中的价值。方法选择100例胃癌患者作为胃癌组,患者采用mFOLFOX6方案,2周为1个疗程,每位患者化疗4个疗程以上。另选择同期在医院体检的健康人群80例作为对照组,采用流式细胞仪技术检测两组外周血T淋巴细胞亚群水平。结果化疗前胃癌组外周血CD3+、CD4+、CD4+/CD8+显著低于对照组,CD8+显著高于对照组,差异有统计学意义(P﹤0.01)。Ⅰ~Ⅱ期胃癌患者外周血CD3+、CD4+、CD4+/CD8+显著高于Ⅲ~Ⅳ期,CD8+显著低于Ⅲ~Ⅳ期,差异有统计学意义(P﹤0.01)。不同疗效的胃癌患者化疗前外周血T淋巴细胞亚群水平比较差异无统计学意义(P﹥0.05),化疗后CR+PR组、SD组、PD组外周血CD3+、CD4+、CD4+/CD8+显著降低,CD8+显著上升,差异有统计学意义(P﹤0.01),且CR+PR组外周血CD3+、CD4+、CD4+/CD8+显著高于SD组和PD组,CD8+显著低于SD组和PD组,差异有统计学意义(P﹤0.01)。结论通过检测血清外周血T淋巴细胞亚群水平能够有助于评估胃癌的病情和预后。

关 键 词:T淋巴细胞  胃癌  临床分期  预后

Clinical significance of peripheral blood T lymphocyte subsets as prognostic markers in patients with gastric cancer
WANG Zhan-mei,CAO Fang-li,QU Lin-li,WANG Huan. Clinical significance of peripheral blood T lymphocyte subsets as prognostic markers in patients with gastric cancer[J]. Oncology Progress, 2016, 14(4). DOI: 10.11877/j.issn.1672-1535.2016.14.04.22
Authors:WANG Zhan-mei  CAO Fang-li  QU Lin-li  WANG Huan
Abstract:Objective To explore the clinical value of peripheral blood T lymphocyte subsets as markers for surveil-lance and prognosis in patients with gastric cancer (GC). Method A total of 100 cases of gastric cancer patients were en-rolled as GC group, treated with mFOLFOX6 regimen, with 2 weeks as 1 cycle, and each patient was given 4 cycles of chemotherapy at least. Another 80 cases of healthy adults in clinic during the same period were included as the control group, and the level of T lymphocyte subsets in peripheral blood of the two groups were detected by flow cytometry. Re-sult Before chemotherapy, the CD3+, CD4+, and CD4+/CD8+were significantly lower, and CD8+was higher in GC group compared with that of control group (P<0.05);The CD3+, CD4+, and CD4+/CD8+in GC patients of I-II stage were significant-ly higher than those of III-IV stage,while the CD8+in the former was significantly lower than that in the latter (P<0.01). There was no significant difference in T lymphocyte subsets level in peripheral blood of GC patients with different re-sponse before chemotherapy (P>0.05), After treatment, the CR+PR group, SD group, PD group had decreased peripheral blood CD3+, CD4+, and CD4+/CD8+, and increased CD8+(P<0.01), CD3+, CD4+, and CD4+/CD8+in CR+PR group were signifi-cantly higher than, while CD8+was significantly lower than those in SD group and PD group (P<0.01). Conclusion De-tecting the T lymphocyte subsets in peripheral blood is beneficial in monitoring disease condition and predicting progno-sis.
Keywords:T lymphocytes  gastric cancer  clinical staging  prognosis
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