| 胎膜组织BMP-2及MMP-9的表达及与胎膜早破的关系 |
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| 引用本文： | 李庆姝,漆洪波.胎膜组织BMP-2及MMP-9的表达及与胎膜早破的关系[J].实用妇产科杂志,2010,26(2). |
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| 作者姓名： | 李庆姝 漆洪波 |
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| 作者单位： | 重庆医科大学附属第一医院,重庆,400016 |
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| 基金项目： | 重庆市自然科学基金项目，重庆市卫生局科研基金资金项目 |
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| 摘 要： | 目的:探讨胎膜组织骨形成蛋白-2(BNP-2)及基质金属蛋白酶-9(MMP-9)与胎膜早破(PROM)发生的关系.方法:选择足月临产产妇、足月PROM产妇、早产临产产妇、早产PROM产妇及足月未临产产妇(对照组)各18例,分娩后取破口处胎膜组织,采用免疫组织化学法染色,并使用病理影像多媒体图文操作系统对BMP-2、MMP-9阳性表达物的面积积分光密度(AIOD)进行半定量分析.结果:①胎膜组织中BMP-2和MMP-9阳性表达的AIOD在足月临产组、足月PRON组、早产临产组、早产PROM组均高于对照组,差异均有统计学意义(P<0.0071);②足月PROM组BMP-2和MMP-9高于足月临产组(P=0.0065,P=0.0069);早产PROM组BNP-2和NMP-9高于早产临产组(P=0.0069,P=0.0052);早产PROM组BMP-2和MMP-9高于足月PROM组(P=0.0037,P=0.0065);③5组胎膜组织中BMP-2和MMP-9的表达均呈明显正相关(r_s=0.76159,P<0.0001).结论:BMP-2和MMP-9与胎膜破裂的发生密切相关,胎膜组织中BMP-2与MMP-9的表达水平相关.
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| 关 键 词： | 骨形成蛋白-2 基质金属蛋白酶-9 胎膜早破 |
The Relationship between the Expression of Bone Morphogenetic Protein-2 and Matrix Metalllopro Teinase-9 in Fetal Membrane and Premature Rupture of Membranes |
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| LI Qingshu,QI Hongbo.The Relationship between the Expression of Bone Morphogenetic Protein-2 and Matrix Metalllopro Teinase-9 in Fetal Membrane and Premature Rupture of Membranes[J].Journal of Practical Obstetrics and Gynecology,2010,26(2). |
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| Authors: | LI Qingshu QI Hongbo |
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| Institution: | LI Qingshu,QI Hongbo(The First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China)Corresponding author:Qi Hongbo |
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| Abstract: | Objective:To study the correlation between the bone morphogenetic proteins(BMP-2)and matrix metalloproteinase-9(MMP-9)in fetal membrane and premature rupture of membranes.Methods:18 samples were selected separately from each of the following groups:puerpera with term pregnancy in labor,puerpera with term premature rupture of membranes(PROM),puerpera in preterm labor,puerpera with preterm PROM and puerpera with term pregnancy not in labor(control group).After labor,fetal membranes in the rupture site were ta... |
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| Keywords: | Bone morphogenetic proteins-2 Matrix metalloproteinase-9 Premature rupture of membranes |
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