砷中毒大鼠体内各脏器、组织中砷的分布

目的 研究砷中毒大鼠体内各脏器组织中砷的分布，为地方性砷中毒的治疗提供科学依据。方法 用亚砷酸钠（NaAsO2）诱导出大鼠亚急性砷中毒模型，采用超热中子活化法测定大鼠的肝、肺、肾、脾、心、脑、卵巢、睾丸、肌肉9种脏器组织中A5的含量。结果 中毒组大鼠各脏器组织中砷的含量均极显著高于正常对照组（P〈0．01或P〈0．001）。且砷在各脏器中的浓度并非均匀分布。在中毒组脏器组织中的浓度遵循脾〉肺〉肝〉肾〉卵巢〉心脏〉脑〉肌肉〉睾丸。结论 砷在脾、肺、肝、肾等脏器中大量的蓄积，可能导致这些器官细胞的损伤。

Distribution of arsenic in arsenic-poisoning rat organs

Objective To study the distribution of arsenic(As) in certain important rat tissues(liver,spleen,kidney,lung,heart,brain,ovary,testis and muscle) of arsenic-poisoning rat and to provide scientific information of treatment of endemic arsenic disease.Methods NaAsO_2 injection was used to induce model subacute arsenic-poisoning rat.Epithermal neutron activation analysis(ENAA) was used to analyze As concentration in the rat organs.Results Arsenic levels in various organs of As-poisoning rats were significantly higher than the control groups(P<0.01or P<0.001).The distribution of As in various organs was not equal.The concentration of As dropped down following the sequence of spleen, lung,liver,kidney,ovary,heart,brain,muscle,and testis. Conclusions In As-poisoning rats,As is enriched in spleen,lung,liver,and kidney,this may be an important damaging mechanism to cells of liver,kidney,lung,and spleen.