妊娠期高血压疾病患者血浆线粒体偶联因子6的变化

目的:探讨血浆线粒体偶联因子6(mitochondrial coupling factor6,CF6)与妊娠期高血压疾病的关系。方法:43例妊娠期高血压疾病孕晚期妇女,放免法测定血浆CF6和前列环素I2(PGI2)的浓度,并与正常晚孕妇女及正常未孕育龄妇女相比较。结果:⑴妊娠期高血压疾病组产前血浆CF6浓度高于正常晚孕组(t=9.25,P<0.001),而PGI2的浓度(t=4.23,P<0.001)及PGI2/CF6(t=5.66,P<0.001)低于正常晚孕组,差异均有显著性。产后1周,两组产妇血浆CF6与PGI2水平均接近于正常未孕妇女,但妊娠期高血压疾病组PGI2/CF6比值仍然低于正常晚孕组(t=3.02,P<0.05)。⑵分娩前血浆CF6浓度及PGI2呈负相关(r=-0.59,t=5.8,P<0.001)。结论:CF6可能通过抑制PGI2合成,参与妊娠期高血压的发生。

Plasma Concentration of Coupling Factor 6 in Gestational Hypertension Patients

Objective To investigate the relationship between plasma mitochondrial coupling factor 6 and hypertensive disorder complicating pregnancy. Methods A case-control study was performed with 43 hypertensive disorder complicating pregnancy and 21 normal pregnant women and 21 normal non-pregnant women.Plasma CF6 and PGI2 concentration were measured with radioimmunoassay. Results ⑴Plasma concentration of CF6 in hypertensive disorder complicating pregnancy group was higher than that in normal pregnant group before delivery (t=9.25,P<0.001),while the concentration of PGI2 (t=4.23,P<0.001) and PGI2/CF6 (t=5.66,P<0.001) was lower than normal pregnant women.Postpartum a week,the concentration of CF6 and PGI2 in maternal plasma was closer to the normal non-pregnant women,but PGI2/ CF6 in hypertensive disorder complicating pregnancy was still lower than normal pregnant women (t=3.02,P<0.05). ⑵There was a negatively correlated between CF6 and PGI2 level before delivery (r=-0.59,t=5.8,P<0.001). Conclusions CF6 may inhibit PGI2 sythesis,and participate in hypertensive disorder of pregnancy in patients with hypertension.