Sequence comparison of the VP7 gene encoding the outer capsid glycoprotein among animal and human group C rotaviruses |
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| Authors: | H. Tsunemitsu B. Jiang L. J. Saif |
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| Affiliation: | (1) Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, Ohio, USA;(2) Viral Gastroenteritis Section, Centers for Disease Control and Prevention, Atlanta, Georgia, USA;(3) Present address: Hokkaido Branch, National Institute of Animal Health, Sapporo, Hokkaido, Japan;(4) Present address: The Wyeth-Lederle Vaccines and Pediatrics Division, American Home Products Corporation, West Henrietta, New York, USA |
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| Abstract: | Summary The nucleotide sequences of the outer capsid glycoprotein (VP7) genes from the Shintoku bovine and the HF and WH porcine group C rotaviruses were determined and compared with those of the published corresponding genes from the Cowden porcine and Ehime human group C rotaviruses. The VP7 genes of all 5 strains were 1063 nucleotides in length and possess one open reading frame encoding a polypeptide of 332 amino acids. Comparative analysis of the deduced amino acid sequences indicated that 85.2–97.0% identity was observed for the VP7 of the serotypically related strains of group C rotaviruses (Cowden, WH and Ehime) whereas 69.9–74.7% identity was observed among the serotypically distinct strains (Shintoku; Cowden, WH and Ehime; and HF). At least 8 variable regions in the VP7 were recognized among serotypically distinct strains, and these locations were similar to those of the variable regions in the VP7 of group A rotaviruses. |
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