曲美他嗪联合治疗不稳定型心绞痛的临床疗效观察

目的:观察曲美他嗪联合治疗不稳定型心绞痛(UAP)的临床疗效。方法:选择UAP患者86例,随机均分为两组:常规治疗组给予硝酸盐制剂、β-受体阻滞剂或钙拮抗剂、低分子肝素等,联合治疗组在常规治疗的基础上加用曲美他嗪20mg,tid。两组均治疗12周,观察治疗前后心率、血压、收缩压与心率乘积、每日硝酸甘油用量、24h心电图ST段最大下移幅度、总下移时间及24h缺血的次数及不良反应。结果:与常规组比较,在缺血发作次数、ST段最大下降幅度、总缺血时间减少、每日硝酸甘油用量指标上联合治疗组比常规治疗组显效率更高、疗效更好,有显著性差异(P<0.01)。结论:传统药物辅以曲美他嗪是治疗UAP的一种安全有效的新方法,疗效确切,值得临床推广使用。

The Clinical Therapeutic Effects of Trimetazidine Combined with Usual Therapy for Unstability Angina Pectoris

Objective:To evaluate the clinical therapeutic effects of trimetazidine combined with usual therapy for unstability angina pectoris.Methods: 86 patients with unstable angina pectoris were randomized into routine treatment group and combined treatment group.In the routine treatment group patients accepted the treatment with nitrate,calcium antagonist,angiotensin-converting enzyme inhibitor,β-blocker and aspirin.In the combined treatment group trimetazidine(20mg,3 times daily) was given in addition to routine therapy.The treatment durations in both groups were 12 weeks.The symptoms,heart rate,blood pressure,ambulatory 24-hour electrocardiography and side effects were observed.Results: The treatment efficacy of the trimetazidine group was better than that of the routine treatment group(P<0.01),the reductions of the number of ischemic episodes,maximal ST-segment depression and the total time of ischemic episodel were more significant(P<0.01).Conclusions: Combination therapy of trimetazidine and conventional drugs releases unstable angina pectoris more effectively.Trimetazidine can improve the unstability angina pectoris in patients.So it is valuable to be spread broadly in clinic.