肝病患者庚型肝炎病毒感染的研究

目的 研究肝病患者庚型肝炎病毒感染状况。方法 用酶链免疫吸附试验（ＥＬＩＳＡ）检测１５４例门诊和住院肝病患者（均无输血史）的抗－ＨＧＶ，１５４例中有５４例同时采用逆转录聚合酶链反应（ＲＴ－ＰＣＲ）检测ＨＧＶ ＲＮＡ，分别计算抗－ＨＧＶ和ＨＧＶ ＲＮＡ的阳性率。以ＨＧＶ ＲＮＡ阳性为ＨＧＶ感染的判断标准，来分析各类肝病患者ＨＧＶ感染状况。结果 １５４例肝病患者抗－ＨＧＶ阳性者３１例，阳性率２０．１３

The study on hepatitis G vrus infection among patients with liver diseases

Objective To investigate the hepatitis G virus(HGV) infection among patients with liver diseases.Methods Anti HGV was detected by ELISA among 154 patients with liver diseases (no history of blood transfusion), 54 of them, HGV RNA was detected by RT PCR concomitantly. The rates of anti HGV and HGV RNA were calculated, respectively. The positivity of HGV RNA was taken as diagnostic criteria for HGV infection in different kinds of liver disease.Results Of 154 patients with liver diseases, anti HGV was positive in 31 patients, the detectable rate of anti HGV was 20 13%.HGV RNA was detected in 13 of 54 patients, the detectable rate was 24 07%. The positive rates of HGV RNA tested in 35 patients with chronic hepatitis and 6 patients with fatty liver were 20 00%(7/35) and a ratio of 5/6, respectively.Conclusion (1)HGV infection is considerably prevalent among patients with nontransfusion transmitted sporadic hepatitis. (2)HGV is a responsible agent for chronic hepatitis. (3)The clinical significance of detectable HGV RNA in patients with fatty liver remains for further study.