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Behavioral Mediators of Treatment Effects in the Weight Loss Maintenance Trial
Authors:J. W. Coughlin Ph.D.  C. M. Gullion Ph.D.  P. J. Brantley Ph.D.  V. J. Stevens Ph.D.  A. Bauck B.S.  C. M. Champagne Ph.D.  A. T. Dalcin R.D.  K. L. Funk M.S.   R.D.  J. F. Hollis Ph.D.  G. J. Jerome Ph.D.  L. F. Lien M.D.  C. M. Loria Ph.D.  V. H. Myers Ph.D.  L. J. Appel M.D.
Affiliation:1. Johns Hopkins University School of Medicine, 600 North Wolfe Street, Meyer 101, Baltimore, MD, 21287, USA
2. Kaiser Permanente Center for Health Research, Oakland, CA, USA
3. Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USA
4. Towson University, Towson, MD, USA
5. Duke University Medical Center, Durham, NC, USA
6. National Heart, Lung, and Blood Institute, Bethesda, MD, USA
7. Klein Buendel, Inc., Golden, CO, USA
Abstract:

Background

The Weight Loss Maintenance Trial tested strategies for maintenance of weight loss. Personal contact was superior to interactive technology and self-directed conditions.

Purpose

We aimed to identify behavioral mediators of the superior effect of personal contact vs. interactive technology and of personal contact vs. self-directed arms.

Methods

Overweight/obese adults at risk for cardiovascular disease (n?=?1,032) who lost at least 4 kg were randomized to personal contact, interactive technology, or self-directed. After 30 months, 880 participants had data on weight and behavioral strategies.

Results

Reported increase of intake of fruits and vegetables and physical activity and more frequent self-weighing met criteria as mediators of the better outcome of personal contact vs. interactive technology. Increased intake of fruits and vegetables, more frequent self-weighing, and decreased dessert consumption were mediators of the difference between personal contact vs. self-directed.

Conclusion

Inducing changes in the identified behaviors might yield better outcomes in future weight loss maintenance trials. (ClinicalTrials.gov number NCT00054925)
Keywords:
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