Computer-aided Diagnosis of Proliferative Diabetic Retinopathy via Modeling of the Major Temporal Arcade in Retinal Fundus Images |
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Authors: | Faraz Oloumi Rangaraj M Rangayyan Anna L Ells |
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Institution: | 1. Department of Electrical and Computer Engineering, Schulich School of Engineering, University of Calgary, Calgary, AB, Canada, T2N 1N4 2. Division of Ophthalmology, Department of Surgery, Alberta Children’s Hospital, Calgary, AB, Canada, T3B 6A8
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Abstract: | Monitoring the openness of the major temporal arcade (MTA) and how it changes over time could facilitate diagnosis and treatment of proliferative diabetic retinopathy (PDR). We present methods for user-guided semiautomated modeling and measurement of the openness of the MTA based on Gabor filters for the detection of retinal vessels, morphological image processing, and a form of the generalized Hough transform for the detection of parabolas. The methods, implemented via a graphical user interface, were tested with retinal fundus images of 11 normal individuals and 11 patients with PDR in the present pilot study on potential clinical application. A method of arcade angle measurement was used for comparative analysis. The results using the openness parameters of single- and dual-parabolic models as well as the arcade angle measurements indicate areas under the receiver operating characteristics of A z = 0.87, 0.82, and 0.80, respectively. The proposed methods are expected to facilitate quantitative analysis of the architecture of the MTA, as well as assist in detection and diagnosis of PDR. |
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