| 丙咪嗪对人血小板胞浆游离钙的影响 |
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| 引用本文： | 付润芳,贾丹辉.丙咪嗪对人血小板胞浆游离钙的影响[J].河南医学研究,1998,7(4):302-303. |
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| 作者姓名： | 付润芳 贾丹辉 |
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| 作者单位： | 河南医科大学药理教研室，河南医科大学附属卫生学校 |
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| 摘 要： | 目的：观察丙咪嗪体外对人血小板胞浆游离钙的影响。方法：用Ｆｕｒａ２－ＡＭ荧光钙离子指示剂在体外测定人血小板胞浆游离钙离子浓度。结果：丙咪嗪明显抑制凝血酶诱导的血小板胞浆游离钙的升高，ＩＣ５０（ｉｎｈｉｂｉｔｏｒｙｃｏｎｃｅｎｔｒａｔｉｏｎｏｆ５０％）为２０．０μｍｏｌ／Ｌ。丙咪嗪对凝血酶诱导的内钙释放亦有明显抑制作用（Ｐ＜０．０１）。结论：丙咪嗪不仅明显抑制人血小板胞外Ｃａ２＋跨膜内流而且抑制胞内储存Ｃａ２＋释放
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| 关 键 词： | 丙咪嗪 凝血酶 血小板 钙 依他酸 |
Effect of Imipramine on the Cytoplasmic Free Calcium in the Platelets of Human |
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| Fu,Runfang,Jia,Danhui,Wu,Hongxia,et,al.Effect of Imipramine on the Cytoplasmic Free Calcium in the Platelets of Human[J].Henan Medical Research,1998,7(4):302-303. |
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| Authors: | Fu Runfang Jia Danhui Wu Hongxia et al |
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| Abstract: | Objective: To study the effect of imipramine on intraplatelet free calcium concentration in human platelet,that induced by thrombin.Methods: Using Fura 2 AM fluorescence technique.Results: Imipramine inhibited the rise of Ca 2+ ] i induce by thrombin in human platelets in vitro significantly.The values of IC 50 was 20.0 μmol/L,respectively.Conclusion: The results suggest that imipramine not only decreases Ca 2+ influx but also inhibits internal Ca 2+ discharge. |
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| Keywords: | imipramine thrombin platelet Ca 2+ EGTA |
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