uPA系统在子宫内膜异位症中的表达及意义

目的:研究尿激酶型纤溶酶原激活剂(uPA)及其受体(uPAR)和纤溶酶原激活剂抑制剂(PAI-1)在子宫内膜异位症中的表达和意义。方法:采用免疫组化链霉菌抗生物素蛋白-过氧化物酶连接法(S-P法)分别检测30例子宫内膜异位症患者的异位内膜及其相应的在位内膜(研究组)以及30例正常子宫内膜(对照组)中uPA、uPAR、PAI-1的表达。结果:异位内膜和在位内膜及对照组子宫内膜组织中,uPA的表达分别为0.198、0.112、0.079;uPAR的表达分别为0.162、0.119、0.076;PAI-1的表达分别为0.230、0.158、0.080;异位内膜组织中uPA、uPAR、PAI-1与在位内膜及对照组相比,差异均有统计学意义(P<0.05,P<0.01);在位内膜组织中uPA、uPAR、PAI-1与对照组比较,差异亦有统计学意义(P<0.05)。无论是增殖期还是分泌期,异位内膜组织中uPA、uPAR、PAI-1的表达均高于在位内膜及对照组(P<0.05,P<0.01),在位内膜中uPA、uPAR、PAI-1的表达高于对照组(P<0.05)。结论:异位和在位子宫内膜组织中uPA、uPAR、PAI-1表达的变化可能与子宫内膜异位症的发生、发展有关。

Expression and significance of uPA, uPAR, PAI-1 in endometriosis

Objective:To study the clinical significance and expression of uPA,uPAR,PAI-1 in endometriosis.Methods:The expression of uPA,uPAR,PAI-1 in the ectopic and eutopic endometrium were detected by immunohistochemistry streptavidin-biotin peroxidase(S-P) method in 30 patients with endometriosis and in 30 normal women.Results:In the ectopic and eutopic endometrium with endometriosis and in the normal endometrium,the expression of uPA was 0.198,0.112 and 0.079 respectively;the expression of uPAR was 0.162,0.119 and 0.076 respectively;the expression of PAI-1 was 0.230,0.158 and 0.080 respectively.The difference of uPA,uPAR,PAI-1 in the ectopic endometrium and in the eutopic endometrium and the normal endometrium was markedly significant(P<0.05 or P<0.01).The difference of the expression of uPA、uPAR、PAI-1 between ectopic and the eutopic endometrium was also markedly significant(P<0.05).In the whole menstrual period,the expression levels of uPA,uPAR,PAI-1 in the ectopic endometrium was higher than those in the eutopic endometrium with endometriosis and the normal endometrium(P<0.05 or P<0.01).Expression of uPA,uPAR,PAI-1 in the eutopic endometrium was also higher than that in the normal endometrium(P<0.05).Conclusion:The change of expression uPA,uPAR,PAI-1 in ectopic and eutopic endometrium may be related to the pathogenesis of endometriosis.