缺血性心肌病血清内皮素、一氧化氮的变化及临床意义

目的：探讨冠状动脉粥样硬化性心脏病（ＣＨＤ）引起的缺血性心肌病患者血浆中内皮素（ＥＴ）、一氧化氮（ＮＯ）变化的临床意义。方法：测定８０例ＣＨＤ血浆中的ＥＴ、ＮＯ的含量，观察其中２９例缺血性心肌病患者血浆中ＥＴ、ＮＯ的变化，并与２０例正常健康人做对照。结果：缺血性心肌病组平均ＥＴ、ＮＯ较冠心病组ＥＴ、ＮＯ增高，较正常对照组ＥＴ、ＮＯ显著增高（Ｐ〈０．０１）。用直线相关分析ＥＴ与ＮＯ之间改变的关系，ＥＴ与ＮＯ呈正相关，相关系数无统计意义。缺血性心肌病组心肌肥厚以ＥＴ增高为主，与冠心病组比较有显著性差异（Ｐ〈０．０５）。扩张型心肌病组以ＮＯ增高为主与冠心病组比较有有极显著差异（Ｐ〈０．０１）。结论：缺血性心肌病ＥＴ与ＮＯ增高，在促进心肌细胞增生、心肌细胞肥大的病理生理中起主要作用。ＮＯ参与扩张心肌病心肌细胞增生与重构

Changes and Clinical Significance of Serum Endothelin and Nitric Oxide Levels in Patients with Ischemic Cardiomyopathy

Objective:To explore the changes and clinical significance of serum endothelin and nitric oxide levels in CHD patients with ischemic cardiomyopathy.Methods:The serum levels of ET and NO were measured in 80 coronary heat disease (CHD) cases,29 ischemic cardiomyopathy cases and 20 cases of the control. Results:The serum levels of ET and NO in patients with ischemic cardiomyopathy were much higher than those in CHD patients and control cases ( P <0.01). Positive correlation was observed between the ET and NO levels. ET increase was more significant in patients with ischemic cardiomyopathy and difference was observed when compared with the ET level in CHD patients ( P <0.05). NO increase was observed mainly in dilative cardiomyopathy cases and difference was also observed when compared with the NO level in CHD cases ( P <0.01). Conclusions:The increased serum ET and NO levels played an important role in the proliferation and pathophysiology in patients with ischemic cardiomyopathy and NO level was closely related to the pathophysiology in patients with dilative cardiomyopathy.