| MicroRNA and Brain Tumors |
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| 作者姓名： | Xuan Zhou Chunsheng Kang Peiyu Pu |
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| 作者单位： | Xuan Zhou Chunsheng Kang Peiyu Pu Department of Neurosurgery，Tianjin Medical University General Hospital，Laboratory of Neuro-oncology，Tianjin Neurological Institute，Tianjin，300052，China. |
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| 摘 要： | MicroRNAs(miRNAs)were first described in 1993 by Lee and col eagues,and the term microRNA was only introduced in 2001 in a set of three articles in Science1].One of the biggest surprises in the past few years has been the emergence of miRNAs as a major new class of gene expression regulators.Recent studies suggest that miRNA alterations are involved in the initiation and progression of human cancer.The brain tumor, glioblastoma multiforme,is the most malignant and deadly form of gliomas. The prognosis is poor and the median survival with combined radiotherapy and chemotherapy is only 14.6 months.With the discovery of miRNA,the miRNA profiles may become useful biomarkers for brain tumor diagnostics, and miRNA therapy could be a powerful tool for brain tumor prevention and therapeutics.This review outlines the background of miRNA and its expression and therapeutic potential for brain tumors.
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| 关 键 词： | 癌症 治疗方法 RNA 转换模式 |
| 修稿时间： | 2007-05-102007-09-28 |
MicroRNA and brain tumors |
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| Xuan Zhou Chunsheng Kang Peiyu Pu.MicroRNA and Brain Tumors[J].Chinese Journal of Clinical Oncology,2007,4(5):355-359. |
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| Authors: | Xuan Zhou Chunsheng Kang Peiyu Pu |
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| Institution: | Department of Neurosurgery,Tianjin Medical University General Hospital,Laboratory of Neuro-oncology,Tianjin Neurological Institute,Tianjin,300052,China |
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| Abstract: | MicroRNAs(miRNAs)were first described in 1993 by Lee and col eagues,and the term microRNA was only introduced in 2001 in a set of three articles in Science1].One of the biggest surprises in the past few years has been the emergence of miRNAs as a major new class of gene expression regulators.Recent studies suggest that miRNA alterations are involved in the initiation and progression of human cancer.The brain tumor, glioblastoma multiforme,is the most malignant and deadly form of gliomas. The prognosis is poor and the median survival with combined radiotherapy and chemotherapy is only 14.6 months.With the discovery of miRNA,the miRNA profiles may become useful biomarkers for brain tumor diagnostics, and miRNA therapy could be a powerful tool for brain tumor prevention and therapeutics.This review outlines the background of miRNA and its expression and therapeutic potential for brain tumors. |
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