| TNF和IL—1对海马AchE阳性纤维发育的影响 |
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| 引用本文： | 蒋吉英 窦寰宇. TNF和IL—1对海马AchE阳性纤维发育的影响[J]. 潍坊医学院学报, 1998, 20(4): 244-245 |
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| 作者姓名： | 蒋吉英 窦寰宇 |
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| 作者单位： | 潍坊医学院解剖学教研室 |
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| 摘 要： | 探讨肿瘤坏死因子和白细胞介素１对中枢神经发育的作用。方法５０只小鼠射不同浓度的ＴＮＦ和ＩＬ－１后，饲养周或１月行胆碱酯酶染色，观察海马结构内ＡｃｈＥ阳性纤维的变化。结果：海马结构内焦点有大量的ＡｃｈＥ阳性纤维。ＩＬ－１组和ＴＮＦ代浓度组与对照组和ＴＮＦ高浓度相比差异有显著性。结论低浓度ＴＮＦ和ＩＬ－１对海马结构ＡｃｈＥ纤维的发育有调节作用。
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| 关 键 词： | 肿瘤坏死因子 IL－1 海马 AchE 发育 |
EFFECTS OF TNF AND IL 1 ON THE DEVELOPMENT OF HIPPCAMPAL AchE POSITIVE FIBER |
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| Jiang Jiying,Dou Huanyu,Wang Juxin,et al. EFFECTS OF TNF AND IL 1 ON THE DEVELOPMENT OF HIPPCAMPAL AchE POSITIVE FIBER[J]. Journal of Weifang Medical College, 1998, 20(4): 244-245 |
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| Authors: | Jiang Jiying Dou Huanyu Wang Juxin et al |
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| Affiliation: | Jiang Jiying,Dou Huanyu,Wang Juxin,et al Department of Anatomy,Weifang Medical College,Weifang,261042 |
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| Abstract: | Objective The present research studied the effects of TNF (tumor necrosis factor) and IL 1(interleukin 1) on the development of central nerve system.Method Using Acetycholinesterase(AchE) histochemical method,the density of AchE positive fibers in fifty mice hippocampus was investigated after injection of TNF and IL 1.Result There were abundant AchE positive fibers in the hippocamus.The density of AchE positive fibers in the hippocampus,after TNF and IL 1 injection,was different depending on the dose of TNF.Conclusion TNF and IL 1 had regulative role in the development of AchE positive fibers in hippocampus. |
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| Keywords: | tumor necrosis factor interleukin 1 hippocapus AchE development |
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