Adenovirus-mediated gene transfer of TIMP-4 reduces neointimal hyperplasia in balloon-injured rat carotid artery |
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| Authors: | Zhong Li He Guoxiang Song Zhiyuan Ran Boli |
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| Institution: | Zhong Li*,He Guoxiang,Song Zhiyuan,Ran Boli Department of Cardiology,Southwest Hospital,Third Military Medical University,Chongqing 400038,China |
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| Abstract: | Objective:To determine the effects of a recombinant replication-deficient adenovirus encoding human tissue inhibitor of metalloproteinase-4(Ad.TIMP-4) on vascular smooth muscle cell(VSMC) function in vitro and neointimal development in the injured rat carotid artery.Methods:Western blotting,gelatin zymography and reverse zymography were used to characterize the expression and functional activity of the TIMP-4 secreted by Ad.TIMP-4-infected VSMCs.The migration and proliferation of VSMCs in vitro were separat... |
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| Keywords: | Tissue inhibitor of metalloproteinase-4 Vascular smooth muscle cells Restenosis Vascular injury |
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