| 血管紧张素Ⅱ1型受体基因A1166C多态性与高血压肾脏损害相关性研究 |
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| 引用本文： | 朱小玲,李庆祥,张宇清,慈维苹,艾辉,陈祚,吴海英,颜红兵,刘国仗. 血管紧张素Ⅱ1型受体基因A1166C多态性与高血压肾脏损害相关性研究[J]. 心肺血管病杂志, 2006, 25(3): 135-137 |
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| 作者姓名： | 朱小玲 李庆祥 张宇清 慈维苹 艾辉 陈祚 吴海英 颜红兵 刘国仗 |
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| 作者单位： | 1. 100029,首都医科大学附属北京安贞医院心肺血管疾病抢救中心
2. 中国医学科学院心血管病研究所,中国协和医科大学北京阜外心血管病医院 |
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| 摘 要： | 目的:探讨血管紧张素Ⅱ1型受体(AT1R)A1166C多态性与高血压、高血压肾脏损害的关系。方法:入选188例原发性高血压患者进行尿微量白蛋白和AT1R基因A1166C多态性测定。结果:AA基因型与AC基因型收缩压分别为(149·1±20·8)mmHg(1mmHg=0·133kPa)和(137·8±22·6)mmHg,2组间差异有显著性(P=0·013)。AC基因型携带者尿微量白蛋白尿异常者明显增多,差异有显著性(P=0·006)。结论:AT1R基因A1166C多态性可能与原发性高血压和高血压肾脏损害有关。
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| 关 键 词： | 高血压 血管紧张素Ⅱ1型受体 微量白蛋白尿 多态性 |
| 修稿时间： | 2005-12-28 |
The relationship between angiotensin Ⅱ type 1 receptor gene A1166C polymorphism and renal damage in essential hypertension |
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| ZHU Xiaoling,LI Qingxiang,ZHANG Yuqing,CI Weiping,AI Hui,CHEN Zuo,WU Haiying,YAN Hongbing,LIU Guozhang. The relationship between angiotensin Ⅱ type 1 receptor gene A1166C polymorphism and renal damage in essential hypertension[J]. Journal of Cardiovascular and Pulmonary Diseases, 2006, 25(3): 135-137 |
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| Authors: | ZHU Xiaoling LI Qingxiang ZHANG Yuqing CI Weiping AI Hui CHEN Zuo WU Haiying YAN Hongbing LIU Guozhang |
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| Abstract: | Objective:To investigate the relationship between angiotensin Ⅱ type 1 receptor(AT1R) gene A1166C polymorphism and renal damage in essential hypertension.Method:188 patients with essential hypertension were enrolled into this study. Every people measured microalbuminuria. Genomic DNA was extracted from peripheral blood leukocytes by standard method. Polymerase chain reaction(PCR)combined with restriction enzyme digestion was used to detect the polymorphism. Result: SBP in AA genotype was significantly higher than AC genotype(P=0.013). The subjects with microalbuminuria increased significantly in AC genotype(P=0.006).Conclusion:AT1R gene A1166C polymorphism may be possibly related to was associated with essential hypertension and its renal damage. |
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| Keywords: | Hypertension AngiotensinⅡtype 1 receptor Microalbuminuria Polymorphism |
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