| 纳米铜/聚合物复合材料宫内节育器对猕猴宫腔液t-PA、PAF、PGE_2水平的影响 |
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| 引用本文： | 甄波,朱长虹,谢长生,刘子龙,蔡水洲,沈娅,狄海红,刘合芳.纳米铜/聚合物复合材料宫内节育器对猕猴宫腔液t-PA、PAF、PGE_2水平的影响[J].生殖与避孕,2006,26(8):467-471. |
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| 作者姓名： | 甄波 朱长虹 谢长生 刘子龙 蔡水洲 沈娅 狄海红 刘合芳 |
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| 作者单位： | 1. 华中科技大学同济医学院计划生育研究所,武汉,430030
2. 华中科技大学材料科学院,武汉,430000 |
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| 摘 要： | 目的:探讨纳米铜/聚合物复合材料宫内节育器(IUD)对置器后子宫出血、疼痛的影响。方法:选择具规律月经周期且有生育史的育龄猕猴30只,分为空白对照组、裸铜组、生物材料组、低剂量纳米铜组(10μg/220mm2)、高剂量纳米铜组(20μg/220mm2),每组6只。采用酶联免疫吸附法(ELISA)检测各组置器后子宫宫腔冲洗液中t-PA、PAF、PGE2水平。结果:①与空白组相比,裸铜组宫腔冲洗液中t-PA及PGE2水平显著升高;②与裸铜组相比,纳米铜组t-PA及PGE2水平均显著降低;③除裸铜组PAF显著高于空白组外,其他各组间PAF水平无明显差异。结论:纳米铜IUD可减少对子宫t-PA和PGE2水平的影响,因而可能减轻置入IUD引起的子宫异常出血、疼痛副反应。
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| 关 键 词： | 纳米铜/聚合物复合材料宫内节育器 猕猴 宫腔液 t-PA PAF PGE2 |
| 文章编号： | 0253-357X（2006）08-0467-05 |
| 收稿时间： | 2006-03-27 |
| 修稿时间： | 2006年3月27日 |
Impact of Nano-Cu/LDPE-IUD on the Level of t-PA、 PAF、 PGE2 in the Uterine Fluid of Macaca mulatta |
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| Bo ZHEN,Chang-hong ZHU,Chang-sheng XIE,Zi-long LIU,Shui-zhou CAI,Ya SHEN,Hai-hong DI,He-fang LIU.Impact of Nano-Cu/LDPE-IUD on the Level of t-PA、 PAF、 PGE2 in the Uterine Fluid of Macaca mulatta[J].Reproduction and Contraception,2006,26(8):467-471. |
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| Authors: | Bo ZHEN Chang-hong ZHU Chang-sheng XIE Zi-long LIU Shui-zhou CAI Ya SHEN Hai-hong DI He-fang LIU |
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| Institution: | 1. Family Planning Research Institute, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030;2. Material Science College, Huazhong University of Science and Technology, Wuhan, 430030 |
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| Abstract: | Objective:To explore the impact of Nano-Cu/LDPE-IUD on uterine bleeding and pain.Method:Thirty normal sexual mature Rhesus monkeys which had previously pregnant history,with normal men-struation were chosen as research objectives and divided into five model groups,including blank control group,biomaterial group,Cu-IUD group,low dose(10 μg/220 mm2)and high dose(20 μg/220 mm2)Nano-Cu/LDPE-IUD group.The enzyme linked immunosorbent assay(ELISA)was performed to estimate the level of t-PA,PAF,PGE2 in the uterine fluid of IUD-inserted Macaca mulatta.Result:Compared with control group,the levels of both t-PA and PGE2 in the uterine fluid of Cu-IUD group significantly increased.Compared with Cu-IUD group,the levels of both t-PA and PGE2 in the uterine fluid of Nano-Cu/LDPE-IUD group significantly decreased(P<0.05).Except that the level of PAF in Cu-IUD group was significantly higher than that in control group(P<0.05),there was no significant difference among other groups.Conclusion:Nano-Cu/LDPE-IUD could lessen abnormal bleeding and pain caused by Cu-IUD through depress the rising level of t-PA and PGE2. |
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| Keywords: | t-PA PAF PGE2 |
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