改性壳聚糖类肝素化合物血液相容性研究

选用壳聚糖为原材料，通过改性在其主链上引入-COOH和-SO3H两种基团制备成类肝素化合物。研究反应过程中羧甲基和磺酸基取代度的影响因素及不同取代位置，不同取代度的化合物复钙时间和溶血率。结果表明，壳聚糖类肝素化合物的抗凝血性能是由甲壳糖主链上引入的-COOH和-SO3H两种基团的协同效应产生的，血液相溶性的优劣主要取决于-COOH和-SO3H两者的比例。N—CM，O—SO3H壳聚糖，当N—羧甲基取代度为0．585，O—磺酸基取代度为0．593时其抗凝血性能最优。而N—SO3H，O—CM壳聚糖，当N—磺酸基取代度为0．689，O—羧甲基取代度为0．593时，其血液相溶性最佳。

Study blood compatibility properties of heparin-like compoundsof chitosan

Heparin-like compounds were prepared by introducing -COOH and -SO3H into the main chains of chitosan. Comparisons of recalciffication times and degree of hemolysis of these compounds were related to the position and degree of subtitution of each individual group. Results showed that the blood compatibility properties of heparin-like compounds of chitosan were simultaneously affected by both -COOH and -SO3H in the main chains of chitosan. N-CM- O-SO3 H chitosan had good blood compatibility property when the degree of substitution of N-carboxymethy was 0.585 and that of O-sulfated group was 0.417; N-SO3H- O-CM chitosan had good blood compatibility when the degree of substitution of N-sulfated group was 0.689 and that of O-carboxymethy was 0.593.