| 盐酸氯雷他定一般药理学及毒理学实验研究 |
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| 引用本文： | 隋丽娅,祝清芬,谢寅,彭新杰.盐酸氯雷他定一般药理学及毒理学实验研究[J].中国实用医药,2007,2(2):46-48. |
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| 作者姓名： | 隋丽娅 祝清芬 谢寅 彭新杰 |
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| 作者单位： | 1. 山东省药品检验所,山东济南,250012
2. 中国药品生物制品鉴定所,北京,100050 |
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| 摘 要： | 目的观察盐酸氯雷他定的一般药理试验及急性毒性试验,以证明其安全性。方法采用多计量盐酸氯雷他定对不同动物进行一般药理学及毒理学试验。结果小鼠灌胃给予5mgkg-1、10mgkg-1和20mgkg-1盐酸氯雷他定对小鼠的自主活动和给予阈下催眠剂量戊巴比妥钠的小鼠入睡的数目均无明显影响。十二指肠给予1.5mgkg-1、3.0mgkg-1和6.0mgkg-1盐酸氯雷他定对麻醉猫的心血管和呼吸系统亦无明显影响。小鼠灌胃给予盐酸氯雷他定,LD50=1373.85mg.kg-1(95%可信限1114.61～1646.66mg.kg-1);小鼠腹腔注射给盐酸氯雷他定,LD50=527.96mg.kg-1(95%可信限446.22～625.29mg.kg-1)。
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| 关 键 词： | 盐酸氯雷他定 药理作用 |
| 文章编号： | 1673-7555[2007]02-46-02 |
The Pharmacology and Toxicology of Lorapadine Hydrochloride |
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| SUI Li-ya,ZHU Qing-fen,XIE Yin,PENG Xin-jie.The Pharmacology and Toxicology of Lorapadine Hydrochloride[J].China Practical Medical,2007,2(2):46-48. |
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| Authors: | SUI Li-ya ZHU Qing-fen XIE Yin PENG Xin-jie |
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| Abstract: | Objective To observe general pharmacological action and acute toxicity test to verify the safety of lorapadine hydrochloride.Methods General pharmacological and toxicological tests in different kinds of animals were conducted by giving multi dose of lorapadine hydrochloride.Results 5mgkg-1,10mgkg-1 and 20mgkg-1 of lorapadine hydrochloride given by stomach affected the autonomous movement of mice slightly,and pentobarbital sodium in sub-threshold hypnotic dose has little effect on the number of asleep mice.1.5mgkg-1,3.0mgkg-1 and 6.0mgkg-1 of lorapadine hydrochloride given by duodenum had not much influence upon cardiovascular and respiratory systems of cats that were anesthetized. |
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| Keywords: | lorapadine hydrochloride pharmacological action |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
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