中医辨证四联疗法联合常规西药治疗急性胰腺炎临床研究

目的:观察中医辨证四联疗法联合常规西药治疗急性胰腺炎肝胆湿热证与胃肠实热证的临床疗效。方法:选取急性胰腺炎肝胆湿热证和胃肠实热证患者80例作为研究对象,按随机数字表法分为研究组和对照组各40例。对照组采用常规西药进行治疗,研究组采用中医辨证四联治疗联合常规西药进行治疗,治疗时间均为14 d。评定2组患者的临床疗效,统计分析2组患者的腹痛消失时间、腹胀消失时间,肠功能恢复时间,血淀粉酶(AMS)、C-反应蛋白(CRP)、白细胞计数(WBC)恢复时间。评价2组CT严重指数(MCTSI)、腹腔内压力评分(IAP)。结果:研究组总有效率为95.0%,高于对照组77.5%(P<0.05)。治疗后,研究组的腹痛消失时间、腹胀消失时间、肠功能恢复时间、AMS恢复时间、CRP恢复时间、WBC恢复时间均低于对照组,差异均有统计学意义(P<0.05)。治疗前,2组MCTSI评分、IAP评分比较,差异无统计学意义(P>0.05)。治疗后,2组MCTSI评分、IAP评分较治疗前降低(P<0.05),且研究组MCTSI评分、IAP评分低于对照组(P<0.05)。结论:中医辨证四联疗法联合常规西药治疗急性胰腺炎肝胆湿热证与胃肠实热证,改善了患者的临床症状,提高了治疗效果,值得在临床上推广。

Clinical Study on Quadruple Therapy Based on Chinese Medicine Syndrome Differentiation Combined with Routine Western Medicine for Acute Pancreatitis

Objective:To observe the clinical effect of quadruple therapy based on Chinese medicine syndrome differentiation combined with routine western medicine for acute pancreatitis with liver-gallbladder damp-heat syndrome and stomach-intestine excessive heat syndrome.Methods:A total of 80 cases of patients with acute pancreatitis with livergallbladder damp-heat syndrome and stomach-intestine excessive heat syndrome were selected as the study objects,and were divided into the study group and the control group according to the random number table method,40 cases in each group.The control group was treated with routine western medicine,and the study group was additionally given quadruple therapy based on Chinese medicine syndrome differentiation on the basis of the treatment of the control group.Both groups were treated for 14 days.The clinical effect in the two groups was evaluated.The disappearance time of abdominal pain and abdominal distension and the recovery time of intestinal function,blood amylase(AMS),C-reactive protein(CRP)and white blood cell count(WBC)in the two groups were counted and analyzed.The scores of modified CT severity index(MCTSI)and intra-abdominal pressure(IAP)in the two groups were evaluated.Results:The total effective rate was 95.0%in the study group,higher than that of 77.5%in the control group(P<0.05).After treatment,the disappearance time of abdominal pain and abdominal distension and the recovery time of intestinal function,AMS,CRP and WBC in the study group were lower than those in the control group,differences being significant(P<0.05).Before treatment,there was no significant difference being found in the comparison of the scores of MCTSI and IAP in the two groups(P>0.05).After treatment,the scores of MCTSI and IAP in the two groups were decreased when compared with those before treatment(P<0.05),and the above scores in the study group were lower than those in the control group(P<0.05).Conclusion:For acute pancreatitis with livergallbladder damp-heat syndrome and stomach-intestine excessive heat syndrome,the therapy of quadruple therapy based on Chinese medicine syndrome differentiation combined with routine western medicine improves the clinical symptoms and curative effect of patients,which is worthy of clinical promotion.