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Relationship between physical activity,cognition, and Alzheimer pathology in autosomal dominant Alzheimer's disease
Authors:Stephan Müller  Oliver Preische  Hamid R. Sohrabi  Susanne Gräber  Mathias Jucker  John M. Ringman  Ralph N. Martins  Eric McDade  Peter R. Schofield  Bernardino Ghetti  Martin Rossor  Nick N. Fox  Neill R. Graff-Radford  Johannes Levin  Adrian Danek  Jonathan Vöglein  Stephen Salloway  Chengjie Xiong  Christoph Laske
Affiliation:1. Section for Dementia Research, Department of Cellular Neurology, Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany;2. Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany;3. German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany;4. Centre of Excellence for Alzheimer''s Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Perth, Australia;5. Department of Biomedical Sciences, Macquarie University, Sydney, NSW, Australia;6. Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany;7. Memory and Aging Center, Keck School of Medicine of USC, Los Angeles, CA, USA;8. University of Pittsburgh School of Medicine, Department of Neurology, Pittsburgh, PA, USA;9. Neuroscience Research Australia, Randwick, Sydney, NSW, Australia;10. School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia;11. Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, IN, USA;12. Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, UK;13. Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA;14. Department of Neurology, Mayo Clinic, Jacksonville, FL, USA;15. German Center for Neurodegenerative Diseases (DZNE), München, Germany;p. Department of Neurology, Ludwig-Maximilians University Munich, Munich, Germany;q. Department of Neurology, The Warren Alpert Medical School of Brown University, Providence, RI, USA;r. Division of Biostatistics, The Knight Alzheimer''s Disease Research Center, Washington University School of Medicine, St Louis, MO, USA;s. Department of Neurology, Knight Alzheimer''s Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA;t. The Florey Institute, The University of Melbourne, Parkville, Victoria, Australia;u. Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women''s Hospital, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Abstract:

Introduction

Little is known about effects of physical activity (PA) in genetically driven early-onset autosomal dominant Alzheimer's disease (AD).

Methods

A total of 372 individuals participating at the Dominantly Inherited Alzheimer Network study were examined to evaluate the cross-sectional relationship of PA with cognitive performance, functional status, cognitive decline, and AD biomarkers in cerebrospinal fluid. Mutation carriers were categorized as high or low exercisers according to WHO recommendations.

Results

Mutation carriers with high PA showed significantly better cognitive and functional performance and significantly less AD-like pathology in cerebrospinal fluid than individuals with low PA. Mutation carriers with high PA scored 3.4 points better on Mini Mental State Examination at expected symptom onset and fulfilled the diagnosis of very mild dementia 15.1 years later compared with low exercisers.

Discussion

These results support a beneficial effect of PA on cognition and AD pathology even in individuals with genetically driven autosomal dominant AD.
Keywords:Physical activity  Dominantly inherited Alzheimer's disease  Cognitive function  Functional status  Cerebrospinal fluid biomarkers  Mutation carrier
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