Altered cardiac tissue and plasma kininogen levels in hypertensive and diabetic rats |
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Authors: | Sharma J N Kesavarao U Yusof A P |
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Institution: | Department of Pharmacology and Physiology, School of Pharmaceutical Sciences, Universiti Sains Malaysia. jnarain@usm.my |
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Abstract: | The present investigation was aimed at evaluating the cardiac and total plasma kininogen levels, as well as LVWT in hypertensive and diabetic rats. STZ-induced diabetes produced a significant (P < 0.001) rise in mean arterial blood pressure (BP). The LVWT increased (P < 0.001) in SHR with and without diabetes) and diabetic WKYR. The cardiac tissue, as well as total plasma kininogen levels fell significantly (P < 0.001) in diabetic WKYR and SHR with and without diabetes compared to the control WKYR. These findings suggest that reduced kininogen levels may indicate a deficiency in kinin generation in the heart and in the peripheral circulation in diabetic and hypertensive rats. This effect may contribute to the development of LVH. |
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