Interspecies recombination occurs frequently in quinolone resistance-determining regions of clinical isolates of Streptococcus pyogenes |
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| Authors: | Duesberg Christoph B Malhotra-Kumar Surbhi Goossens Herman McGee Lesley Klugman Keith P Welte Tobias Pletz Mathias W R |
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| Affiliation: | Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany. |
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| Abstract: | Fluoroquinolone resistance in Streptococcus pyogenes has been reported only anecdotally, but a recent Belgian surveillance study found a rate of nonsusceptibility of 5.4%. From an analysis of these isolates, we show that interspecies horizontal gene transfer within the parC quinolone resistance-determining region is a frequent phenomenon that might contribute to fluoroquinolone resistance. |
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