健康大学生血清乙型肝炎病毒感染状况及疫苗接种变化趋势分析

目的:研究健康大学生血清乙型肝炎病毒(HBV)感染状况及变化趋势.方法:用酶联免疫吸附实验测大学生血清中HBV抗原-抗体系统,赖氏法检测丙氨酸转氨酶(ALT)活性,问卷调查入学时学生使用乙肝疫苗的情况.结果:1996-2000年5届学生入学时感染模式1感染率逐年下降,感染模式2感染率逐年升高,感染模式3感染率逐年下降但变化不明显;使用乙肝疫苗后产生的抗-HBs入学时维持率为77.36%,少数个体对乙肝疫苗并不敏感;感染模式1学生接受乙肝疫苗全程免疫1次,抗-HBs阳性率与入学前使用乙肝疫苗有一定关系.结论:各感染模式的感染率呈时间变化,ALT异常者应引起高度重视;注射乙肝疫苗对机体产生保护性抗体,抗-HBs作用明显,乙肝疫苗不敏感的人群可能确实存在.

ANALYSIS OF CHANGE TREND OF HBV INFECTION SERUM STATUS AND VACCINATION AGAINST HEPATITIS B IN HEALTHY UNIVERSITY STUDENTS

Objective:To analyse the change trend of hepatitis B virus(HBV) infection serum status and vaccination against hepatitis B in healthy university students.Methods:The HBV serum marker of 3001 new university students was detected by enzyme linked immunosorbent assay,and serum elevated alanine amino-transferase (ALT) was measured by automatic biochemistry analysis instrument.The condition of vaccination against HBV was investigated by visiting every university student at the time of entrance.Results:In 3001 new university students from 1996 to 2000,the positive rate of infection model 1 was decreasing,and infection model 2 was increasing,and infection model 3 was not clear reduced with year by year.77.36% students have still retained positive anti-HBs(Antibody to HBsAg) after vaccination against hepatitis B,but it was sure that a small number of population wasn't susceptible to HBV vaccine.The students with infection model 1 anti-HBS positive rate after inoculation for a complete term were related to inoculated HBV vaccine ever.Conclusion:All of the infection rate in every infection model was changed as time goes on,the population of abnormal ALT must be valued.It is very useful to product anti-HBs by inoculated HBV vaccine,and it is possible that a small amount of population isn't sensitive to HBV-vaccine.