气道高反应性与皮肤过敏反应之间关系分析

为了探讨气道高反应性与皮肤过敏反应之间关系 ,依据哮喘患者作为指示病例确定了 30 0 0个哮喘核心家系 ,对各家系的每位成员逐一询问调查、测定气道反应性和进行皮肤过敏试验。主要计算优势比(or值 )等指标。 1 2 51 6位哮喘核心家系亲属皮肤过敏实验的结果表明 :1 2 5 %的人皮斑阳性 ,而出现皮疹阳性的人占 51 3 %。且男性高于女性、低年龄组 (≤ 35岁 )高于高年龄组 (>35岁 ) ,其差别均有高度显著性 (P<0 0 1 )。哮喘家系中有 1 1 9%的人气道反应阳性 ,其中皮斑阳性与皮疹阳性人群出现气道高反应性分别为1 5 5 %和 1 2 7%。皮斑阳性与皮疹阳性者的气道高反应性发生的危险性均较高 ,OR值分别为 1 1 7和 1 44(P <0 0 1 )。并随着引起皮斑阳性或皮疹阳性过敏原的增多而出现气道高反应性的危险性逐渐增大。显示气道高反应性可能与皮肤过敏反应密切相关

Correlations between atopy and airway hyperresponsiveness

To determine the correlations between atopy and airway hyperresponsiveness(AHR),3000 nuclear families were selected by indicator case of asthma. All of questionaire, methacholine challenge test(5g/L) and skin test(with 12 allergens) were conducted among all relatives in those nuclear families. The data were analysed through the EPI5 01 and SAS6 12 and the odds ratio(OR) was obtained. The results of the skin prick tests on 12516 relatives of the asthma nuclear families declared that the percentages of the positive erythema and rash were 12 5% and 51 3%, respectively. Furthermore, the positive rate of male was higher than that of female( P <0 01). At the meantime, the positive rate under age of 35 was higher than that of people with the age over 35( P <0 01). The prevalence of AHR was 11 9% among all relatives, in which the positive erythema and rash were 15 5% and 12 7%, respectively. Both the positive erythema and rash increased the risk of AHR, and their odds ratio are 1 17 and 1 14( P <0 01), respectively, and the risk of AHR was greater with the increasing of kind of allergens causing the positive erythema or rash. The AHR was related with positive skin prick.