| 双氯芬酸钠缓释胶囊在不同PH中释放度的考察实验 |
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| 引用本文： | 张南生,王武弟.双氯芬酸钠缓释胶囊在不同PH中释放度的考察实验[J].中国药业,2002,11(11):29-30. |
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| 作者姓名： | 张南生 王武弟 |
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| 作者单位： | 1. 温州医学院附属第一医院药剂科,浙江,温州,325000
2. 浙江康乐药业有限公司,浙江,温州,325000 |
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| 摘 要： | 目的：考察不同pH条件下药物的体外释放度。方法：采用不同pH的释放介质,按《中国药典》2000年版体外释放度转篮法测定双氯芬酸钠缓释胶囊的释放情况。结果：该药的释放受pH值的影响较大。结论：采用pH＝6的介质作为体外释放试验较为理想。
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| 关 键 词： | 双氯芬酸钠缓释胶囊 体外释放度 pH值 质量控制 |
| 文章编号： | 1006-4931(2002)11-0029-01 |
| 修稿时间： | 2002年2月1日 |
Releasing Rate of Diclofenac Sodium Sustained - release Capsule in Varied pH |
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| Zhang Nansheng ,Wang Wudi.Releasing Rate of Diclofenac Sodium Sustained - release Capsule in Varied pH[J].China Pharmaceuticals,2002,11(11):29-30. |
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| Authors: | Zhang Nansheng Wang Wudi |
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| Institution: | Zhang Nansheng 1,Wang Wudi 2 |
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| Abstract: | Objective:To study the releasing rate in vitro of the drug in varied pH?Methods:By using dissolution medium with different pH,and according to Basket Turning Method for releasing rate in vitro described in"Chinese Pharmacopoeia"(2000version),the release of diclofenac sodium was assayed.Results:The release of the drug was fairly affected by pH.Conclusion:The neleasing medium with pH =6is the best for in vitro releasing test. |
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| Keywords: | Diclofenac Sodium Sustained -release Capsule Releasing rate Study |
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