| 载脂蛋白E基因多态性与阿托伐他汀调脂疗效的相关性 |
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| 引用本文： | 孙丹,孙玉坤,惠福海,史国兵,赵庆春. 载脂蛋白E基因多态性与阿托伐他汀调脂疗效的相关性[J]. 沈阳药科大学学报, 2011, 28(2): 157-161 |
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| 作者姓名： | 孙丹 孙玉坤 惠福海 史国兵 赵庆春 |
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| 作者单位： | （1. 沈阳军区总医院 药剂科，辽宁 沈阳 110016；2. 大连医科大学 药学院，辽宁 大连 116044；3. 沈阳药科大学 药学院，辽宁 沈阳 110016） |
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| 摘 要： | 目的研究载脂蛋白E基因多态性与阿托伐他汀调脂疗效及肝功影响的相关性。方法采用多聚酶链式反应-限制性内切酶片段长度多态性方法(PCR-RFLP)测定49例血脂异常患者ApoE基因型,测定服用阿托伐他汀治疗前及治疗4周后的血脂及肝功水平,分析基因型与调脂疗效的关系。结果 E3等位基因组服用阿托伐他汀4周后,总胆固醇(TC)降低有统计学意义(P<0.05),而E2、E4等位基因组对血脂水平的降低不明显;各等位基因组间的指标变化程度经过统计分析发现差异无统计学意义。服用阿托伐他汀后E3等位基因的STB与ALT改变较大,但各等位基因组间的肝功指标变化程度差异无统计学意义。结论载脂蛋白E基因多态性对阿托伐他汀调脂疗效差异无统计学意义,对肝功损害无显著影响。
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| 关 键 词： | 载脂蛋白E 他汀类 基因多态性 血脂 肝功 |
| 收稿时间： | 2010-04-01 |
| 修稿时间： | 2010-09-09 |
Correlation between polymorphisms of ApoE gene and the lipid regulatory effect of atorvastatin |
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| SUN Dan,SUN Yu-kun,HUI Fu-hai,SHI Guo-bing,ZHAO Qing-chun. Correlation between polymorphisms of ApoE gene and the lipid regulatory effect of atorvastatin[J]. Journal of Shenyang Pharmaceutical University, 2011, 28(2): 157-161 |
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| Authors: | SUN Dan SUN Yu-kun HUI Fu-hai SHI Guo-bing ZHAO Qing-chun |
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| Affiliation: | SUN Dan1,2,SUN Yu-kun3,HUI Fu-hai3,SHI Guo-bing1,ZHAO Qing-chun1(1.The General Hospital of Shenyang Military Region,Shenyang 110016,China,2.School of Pharmacy,Dalian Medical University,Dalian 116044,3.School of Pharmacy,Shenyang Pharmaceutical University,China) |
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| Abstract: | Objective To study the relationship between apolipoprotein-E(ApoE) restricted fragment length polymorphism and the therapeutic effect of atorvastatin. Methods ApoE genotypes of 49 subjects were tested by means of polymerase chain reaction and restricted fragment length polymorphism.The levels of lipid profile in different genotype patients before and after atorvastatin therapy were compared.Then the association of them with SPSS software was analyzed. Results After 4 weeks,the group carrying the E3 allele h... |
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| Keywords: | apolipoprotein E statins gene polymorphism lipid hepatic function |
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