祛风通络方醇提液对急性脑缺血大鼠脑血流量的影响

目的通过祛风通络方醇提液经颈内动脉冲洗的方法改善急性缺血性中风脑局部的血液循环,来阻断再建的血流与缺血损伤组织间的相互作用,减少缺血再灌注损伤。方法用一个新颖的中空套管进行大脑中动脉阻塞,造成缺血模型,在再灌注的超早期通过颈内动脉对缺血灶进行局部冲洗并与腹腔给药方法进行比较。结果(1)中药组、腹腔给药组与模型组相比各时间段内血流量明显提高,有统计学差异(P<0.01,P<0.05);中药组与腹腔给药组相比,在再灌注后各时间段内血流量变化也有统计学差异(P<0.05);(2)中药组与模型组比,再灌注48 h神经功能缺损明显好转,有高度统计学差异(P<0.01);腹腔给药组与模型组相比,再灌注48 h神经功能缺损评分明显好转,有统计学差异(P<0.05);中药组与腹腔给药组相比,有统计学差异(P<0.05)。结论经颈内动脉冲洗方法是一种有效的治疗方法,它的治疗机理并不是单纯的血液稀释和血容量增加的问题,而与不同药物的局部治疗作用有关。

Effect of Ethanol Extract from Qufeng tongluo Recipe on Cerebral Blood Flow in Rats with Acute Cerebral Ischemia

Objective To study the effect of ethanol extract from Qufeng tongluo recipe on cerebral blood flow (CBF) in rats with acute cerebral ischemic injury. Methods Using a modified MCAO method, the authors established the model and flushed the ischemic territory via ICA with Chinese recipe solutions (Qftl) at the early start of reperfusion that 2 hours after MCAO. Rats of control (ip group) were ip 3 ml Chinese recipe solutions at the right time. Results Compared to model group, CBF of Qftl and ip group was increased significantly (P<0.01,P<0.05 respectively) and neurological deficit scores were increased (P<0.01, P<0.05 respectively). The CBF and neurological deficit score was significantly different between Qftl and ip group (P<0.05). Conclusion (1) Focal flushing via ICA is an effective method. The mechanism of this treatment is not only about blood dilution and capacity increasing, but about focal effects of different medicines.