| Caspase-3在戊四氮急性致痫大鼠脑组织中的表达 |
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| 引用本文： | 郭小明,王薇薇,王荫华,吴逊. Caspase-3在戊四氮急性致痫大鼠脑组织中的表达[J]. 中国康复理论与实践, 2005, 11(5): 343-344 |
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| 作者姓名： | 郭小明 王薇薇 王荫华 吴逊 |
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| 作者单位： | 100034,北京市,北京大学第一医院神经内科 |
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| 摘 要： | 目的 研究caspase-3在戊四氮(pentylenetetrazole，PTZ)急性致痫大鼠脑组织中的表达情况。方法 免疫组织化学SP法显示海马及皮层caspase-3阳性细胞，CMIAS图像分析系统半定量分析caspase-3蛋白的含量。结果 癫痫发作后海马及皮层caspase-3蛋白的表达水平均增加，且海马组织较皮层组织增加更为明显。结论 Caspas-3参与了癫痫后脑组织神经元的凋亡过程；在癫痫发作所致的神经元损伤中，海马较皮层可能更为敏感。
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| 关 键 词： | 癫痫 Caspase-3 细胞凋亡 戊四氮 大鼠 |
| 文章编号： | 1006-9771(2005)05-0343-02 |
| 修稿时间： | 2005-01-13 |
Expression of caspase-3 in the rat brain following pentylenetetrazole-induced epilepsy |
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| GUO Xiao-ming,WANG Wei-wei,WANG Yin-hua,et al.. Expression of caspase-3 in the rat brain following pentylenetetrazole-induced epilepsy[J]. Chinese Journal of Rehabilitation Theory and Practice, 2005, 11(5): 343-344 |
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| Authors: | GUO Xiao-ming WANG Wei-wei WANG Yin-hua et al. |
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| Affiliation: | GUO Xiao-ming,WANG Wei-wei,WANG Yin-hua,et al.Department of Neurology,Peking University First Hospital,Beijing 100034,China |
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| Abstract: | ObjectiveTo investigate the expression of caspase-3 in the brain of acutely pentylenetetrazole(PTZ)-kindled rats.MethodsThe caspase-3 positive cells were revealed using immunohistochemical SP method. CMIAS image analysis system was used to analyse the expression of caspase-3 hemi-quantitatively. ResultsFollowing PTZ induced epilepsy, the expression of caspase-3 increased both in the hippocampus and in the cortex, and that was more remarkable in the hippocampus than in the cortex.ConclusionCaspase-3 may be activated during neuronal apoptosis after epilepsy. Hippocampus is more sensitive to the neuronal damage due to epilepsy than the cortex is. |
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| Keywords: | epilepsy caspase-3 cell apoptosis pentylenetetrazole rat |
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