| P物质对变应性鼻炎动物模型鼻粘膜上皮短路电流的影响 |
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| 引用本文： | 刘涛,杨平常,王斌全.P物质对变应性鼻炎动物模型鼻粘膜上皮短路电流的影响[J].中华耳鼻咽喉头颈外科杂志,1998,33(1):6345. |
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| 作者姓名： | 刘涛 杨平常 王斌全 |
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| 作者单位： | 山西医科大学第一医院耳鼻咽喉科 |
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| 摘 要： | 目的观察Ｐ物质（ＳＰ）作用于变应性鼻炎动物模型鼻粘膜引起的离子分泌改变导致的上皮表面短路电流（Ｓｈｏｒｔ－ｃｉｒｃｕｉｔｃｕｒｒｅｎｔ，Ｉｓｃ）的变化。方法以鸡蛋清蛋白致敏大鼠后，用Ｕｓｓ－ｉｎｇ室技术测定鼻粘膜上皮表面短路电流。并观察神经激肽受体（ＮＫ１）拮抗剂ＣＰ９６３４５、组胺Ｈ１受体拮抗剂吡拉明、Ｈ２受体拮抗剂雷尼替丁和河豚毒素对ＳＰ的阻断作用。结果经ＳＰ刺激，致敏大鼠鼻粘膜表面Ｉｓｃ显著增高。经四种物质预处理均能显著阻断ＳＰ引起的Ｉｓｃ变化。结论ＳＰ经感觉神经末梢释放后，可引起上皮表面离子电位变化、上皮通透性增高等一系列鼻粘膜病理变化。
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| 关 键 词： | 鼻粘膜 P物质 鼻炎.变应性.常年性 河豚毒素 |
Effect of substance P on the short circuit current of nasal mucosal epithelium |
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| Liu Tao,Yang Pingchang,Wang Binquan,et al..Effect of substance P on the short circuit current of nasal mucosal epithelium[J].Chinese JOurnal of Otorhinolaryngology Head and Neck Surgery,1998,33(1):6345. |
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| Authors: | Liu Tao Yang Pingchang Wang Binquan |
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| Institution: | Liu Tao,Yang Pingchang,Wang Binquan,et al. Department of Otolaryngology,First Affiliated Hospital,Shanxi Medical University,Taiyuan,030001 |
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| Abstract: | Objective To observe the changes of epithlial apical membrane short circuit current (Isc) of antigen sensitized rat nasal mucosa with the stimulation of Substances P (SP).Methods The epithelial apical membrane Isc were measured with Ussing chamber technique, and and we observed the blockage to the effect of SP by neurokinin receptor antagonist Cp96345, histamine H 1 receptor antagonist pyrilamine, H 2 antagonist renitidine and neurotoxin respectively. Results The Isc increased significantly with the stimulation of SP. The effect of SP on Isc could be blocked significantly by pretreatment with four substances. Conclusion SP releasing from nervous endings plays the role on elicit a series of pathological changes like enhanced Isc,epithelial permeabilities, etc. |
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| Keywords: | Nasal mucosal Substance P Rhinitis allergic perennial Tetrodotoxin |
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