| 麝香抗栓丸对大鼠实验性脑缺血的保护作用 |
| |
| 引用本文： | 赵红梅,于晓风,曲绍春,徐华丽,睢大筼.麝香抗栓丸对大鼠实验性脑缺血的保护作用[J].中草药,2004,35(7):784-787. |
| |
| 作者姓名： | 赵红梅 于晓风 曲绍春 徐华丽 睢大筼 |
| |
| 作者单位： | 吉林大学药学院,药理教研室,吉林,长春,130021 |
| |
| 摘 要： | 目的观察麝香抗栓丸(SATP)对大鼠实验性脑缺血的保护作用。方法采用大鼠结扎双侧颈总动脉伴低血压模型，探讨SATP对实验性脑缺血大鼠脑含水量、脑组织病理、超氧化物歧化酶(SOD)、丙二醛(MDA)、钙离子(Ca^2 )及乳酸(LA)等指标的影响。结果SATP能明显降低实验性脑缺血大鼠的脑含水量，改善脑组织病理变化，提高脑组织SOD)活性，降低MDA、Ca^2 及LA含量，水丸的作用效果强于蜜丸。结论SATP对大鼠实验性脑缺血具有明显保护作用，可能与其抑制脂质过氧化物损害、提高抗氧化酶活性及降低乳酸酸中毒和细胞内钙超载有关。
|
| 关 键 词： | 麝香抗栓丸 脑缺血 钙离子 丙二醛 超氧化物歧化酶 乳酸 |
| 文章编号： | 0253-2670(2004)07-0784-04 |
| 收稿时间： | 9/3/2003 12:00:00 AM |
Protection of Shexiang Antithrombosis Pill on experimental cerebral ischemia in rats |
| |
| ZHAO Hong-mei,YU Xiao-feng,QU Shao-chun,XU Hua-li and SUI Da-yun.Protection of Shexiang Antithrombosis Pill on experimental cerebral ischemia in rats[J].Chinese Traditional and Herbal Drugs,2004,35(7):784-787. |
| |
| Authors: | ZHAO Hong-mei YU Xiao-feng QU Shao-chun XU Hua-li and SUI Da-yun |
| |
| Institution: | Department of Pharmacology, College of Pharmacy, Jilin University, Changchun 130021, China;Department of Pharmacology, College of Pharmacy, Jilin University, Changchun 130021, China;Department of Pharmacology, College of Pharmacy, Jilin University, Changchun 130021, China;Department of Pharmacology, College of Pharmacy, Jilin University, Changchun 130021, China;Department of Pharmacology, College of Pharmacy, Jilin University, Changchun 130021, China |
| |
| Abstract: | Object To observe the protective effect of Shexiang Antithrombosis Pill (SATP) on experimental cerebral ischemia in rats. Methods In cerebral ischemia model induced by bilateral common carotid artery clamping and controlled hemorrhage to a mean arterial pressure of 6.7 kPa (50 mmHg), cerebral water content, SOD activity, MDA, Ca 2 , and LA contents were measured and the ischemic tissue pathology was observed. Results SATP can decrease cerebral water content, lessen pathological change, increase SOD activity and decrease MDA, Ca 2 , and LA contents. Effect of water pill is better than that of honey pill. Conclusion SATP can protect the cerebral tissue from ischemia injury by suppressing lipid peroxidation. This effect may be related to increasing antioxidase activity and decreasing acidosis of LA and overload of calcium in cell. |
| |
| Keywords: | Shexiang Antithrombosis Pill (SATP) cerebral ischemia Ca2 MDA SOD LA |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《中草药》浏览原始摘要信息 |
| 点击此处可从《中草药》下载免费的PDF全文 |
|
