非小细胞肺癌p16基因表达与放疗敏感性的关系

目的：研究非小细胞肺癌（NSCLC）p16基因的表达与放疗敏感性的关系。方法：采用免疫组化检测68例晚期NSCLC的p16表达，该组病例均予以总量为55Gy的常规放疗，分析p16的表达与放疗疗效之间的关系。结果：有57．4％的晚期肺癌p16阴性表达，并且与癌细胞的分化程度密切相关；68例NSCLC采用放射治疗的疗效与癌细胞p16表达高度相关，p16阳性表达的患者其疗效明显好于p16阴性组的疗效（P〈0．05）。结论：NSCLC中存在高频率的p16基因失活，并且p16基因的表达与否可能影响肿瘤细胞对放射治疗的敏感性，因此检测肺癌p16基因的表达可能有助于判断肺癌对于放射治疗的反应，并藉此判断患者的预后，这对于指导临床肿瘤治疗具有重要的参考意义。

Correlation between p16 gene expression and radiosensitivity in non-small cell lung cancer

Objective:To investigate the correlation between the p16 gene expression and the radiosensitivity in non-small lung cancer(NSCLC).Methods:The expression of p16 gene was determined by immunohistochemistry in 68 specimens of advanced NSCLC.All patients received total 55Gy of conventional irradiation.The correlation between the p16 gene expression and the effect of radiotherapy was analyzed.Results:The negative expression of p16 gene existed in 57.4% of advanced NSCLC,and correlated with the differentiation of the cancer cells.The radiotherapy efficacy in the p16-positive group was superior to that in the p16-negative group (P<0.05),which demonstrated that the p16 expression closely related to the efficacy of radiotherapy.Conclusion:The high frequency of p16 inactivation exists in advanced NSCLC,and is associated with the radiosensitivity.The detection of p16 expression may be helpful to the judgement of radiosensitivity and the prognosis of patients.