Detecting protein losing enteropathy by Tc-99m dextran scintigraphy: A novel experience |
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Authors: | Seema Kapoor Simmi K. Ratan Ravi Kashyap S. K. Mittal K. Rajeshwari H. Rawat Jyoti Venna |
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Affiliation: | (1) Department of Pediatrics, Division of Gastroenterology, MAMC and allied LN Hospital, New Delhi;(2) Department of Nuclear Medicine, INMAS, Timarpur, New Delhi;(3) Department of Pediatric Surgery, PGIMS, Rohtak;(4) GH-13/121, Paschim Vihar, 110087 New Delhi |
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Abstract: | Objective: To evaluate protien using enteropathy by Tc-99m dextran scintigraphy.Methods: Methods for detecting protein loss from the intestine revolve around fecal nitrogen excretion, the clearance of α-1 antitrypsin in stools and by endoscopic biopsy.Result: The diagnosis of protein-losing enteropathy (PLE) can also be established by a scintigraphic method that is noninvasive, simple and requires no patient preparation or motivation. This diagnostic modality can also delineate the site of protein loss, thereby offering a targeted approach, and if need be, surgery. Radiolabelling of a non-protein, noncolloidal, nonparticulate and biofriendly molecule like dextran with Technetium-99m for imaging enteric protein loss was utilized in imaging eight children with PLE.Conclusion: The results were encouraging. The authors advocate the use of this diagnostic tool in identifying patients with PLE, particularly in the pediatric age group. |
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Keywords: | Tc-99m dextran Protein losing enteropathy |
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