类固醇受体辅活化子-1和核受体辅阻遏子在人前列腺不同生长方式表达变化

目的探讨类固醇受体辅活化子-1（SRC-1）、核受体辅阻遏子（NCoR）在人前列腺不同生长方式的表达。方法采用免疫组化两步法检测10例胎儿前列腺（EP）、10例正常前列腺（NP）、20例前列腺增生（BPH）、20例激素依赖性前列腺癌（ADPC）、15例激素非依赖性前列腺癌（AIPC）组织SRC-1、NCoR的表达。结果在AIPC、AD-PC、BPH和EP均检测到SRC-1表达,而NP组织,却无SRC-1的明显表达。SRC-1在AIPC的阳性率较ADPC、BPH和NP明显升高（P〈0.01）,而与EP差异无统计学意义（P〉0.05）。NCoR在AIPC、ADPC、BPH、NP和EP均有表达,但在AIPC的表达则出现明显的降低（P〈0.01）。结论 SRC-1和NCoR表达可能与前列腺的生长发育以及前列腺癌的进展密切相关。

Expression of steroid receptor coactivator-1 (SRC-1) and nuclear receptor corepressor (MCoR) in different growing pattern of prostatic tissues

Objective To explore the gene expression of steroid receptor coactivator-1（SRC-1）、 nuclear receptor corepressor（NCoR） in different growing pattern of prostatic tissues.Methods The expression of SRC-1 and NCoR in prostatic specimens from 10 embryo prostatic（EP）cases、 10 normal prostatic（NP）cases、 20 cases with benign prostatic hyperplasia（BPH）、 20 cases with prostate cancer（ADPC） and 15 cases with recurrence prostate cancer（AIPC） was detected by two stage immunohistochemical medhod respectively.Result The expression of SRC-1 was detected in AIPC、ADPC、 BPH and EP and not in NP,and the positive expression rate of SRC-1 in AIPC is much higher than that in ADPC、 BPH and NP（P0.01）,while there was no significantly difference between AIPC and EP.The expression of NCoR in AIPC、 ADPC、 BPH、 NP and EP was all detected,while the NCoR expression obviously deceased in AIPC（P0.01）.Conclusion The expression of SRC-1 and NCoR may play an important role in the development of prostate and the evolvement of prostate cancer.